Synthesis and biological evaluation of phenstatin metabolites

Eco-Friendly Synthesis and Antiproliferative Evaluation of Some Oxygen Substituted Diaryl Ketones

“…The data in Table 2 showed that compounds 12 and 22 appear as the most potent members of the series with lower EC 50 values against T24 and DU-145 with respect to the reference drug mitomycin C. The biological activity differences of compounds 12 and 22 with respect to their analogues could be attributed to the 3,4,5-trimethoxy substitution on the A-phenyl ring. According to literature precedents, the 3,4,5-trimethoxyphenyl ring is considered essential for the antitubulin activity of a broad variety of antimitotic compounds [36,38,39,40,41,42,43,44,45]. Nevertheless, it should be noted that the EC 50 values of compounds 12 and 22 are two orders of magnitude lower than to that reported to phenstatin when tested in the NCI screen [35] showing a mean panel GI 50 (growth inhibitory) value of 6.01 × 10 −8 M. In addition to the tendency showing that dihydroxynaphthyl analogues are more active than the dihydroxyphenyl derivatives, the vast majority of compounds did not have an adequate selectivity (Table 2), that is they affect both cancer and non-tumor cells in a similar way.…”

Bromlu fenstatin türevlerinin seryum (IV) amonyum nitrat/lityum bromür (CAN/LiBr) ile sentezi ve yoğunluk fonksiyonel teorisi (DFT) ile incelenmesi

“…Optimize edilen bu bileşiklerde ki yapısal parametreler (bağ açıları, bağ uzunlukları ve dihedral açılar) Tablo 1-3'de verilmiştir. of (3,4dimethoxyphenyl) (3,4,5-trimethoxyphenyl) methanone (7)) [23].…”

“…Su fazı diklormetan ile tekrar yıkandıktan sonra organik fazlar birleştirildi. Mg2SO4 üzerinden kurutulup ve çözücüsü uzaklaştırıldıktan sonra EtOAc/hekzan (1:9) kolon kromotoğrafisi yapıldı (SiO2, 70 g) ve diarilmetanon 7 (7,600 g, % 67) beyaz katı olarak elde edildi [23]. (1,1 ekiv.…”

Catalysis direction selective asymmetric polymerization in chiral liquid crystal medium

“…A racemic LC was also synthesized ((R,S)-8BpB2). 2,6-dimethoxyphenyl isocyanide (6) were prepared according to the method described in the literature [20,21].…”