Synthesis and biological evaluation of new symmetric curcumin derivatives

Sribalan, Rajendran; Kirubavathi, Maruthan; Banuppriya, Govindharaj; Padmini, Vediappen

doi:10.1016/j.bmcl.2015.07.088

Cited by 49 publications

(26 citation statements)

References 23 publications

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“…The designed water soluble pyrazole curcumin derivative (PyCurOAc) has been synthesized from the readily available vanillin. The alkylation of vanillin with chloroacetic acid in the presence of sodium hydroxide afforded vanillin acetic acid 2 . The curcumin bisacetic acid 3 was synthesized from 2 with pentadionoe, boron oxide, tri n‐butyl borate and n‐butyl amine.…”

Section: Resultsmentioning

confidence: 99%

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Synthesis of a Water‐Soluble Pyrazole Curcumin Derivative: In Vitro and In Vivo AGE Inhibitory Activity and Its Mechanism

et al. 2017

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The new chemical entity, water‐soluble pyrazole curcumin derivative (PyCurOAc) was designed, synthesized and characterized for the purpose of inhibition of AGE formation. The compound showed an excellent in vitro AGEs inhibition activity than curcumin itself as well as the standard. Further, the AGE inhibition activity was substantiated in vivo using C.elegans as an animal model. The mechanistic investigation for the inhibition of AGEs with PyCurOAc was studied with glod‐4 expressions in C.elegans and glucose trapping method. This study suggests that the synthesized compound could be used to treat the formation of AGEs in hyperglycemic nematodes and higher animals.

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Section: Resultsmentioning

confidence: 99%

“…Hence it was hypothesized that PyCurOAc may possess DPPH radical scavenging activity, hydrogen peroxide scavenger activity, and protein denaturation activity. Thus the PyCurOAc was further tested in vitro antioxidant and protein denaturation studies …”

Section: Resultsmentioning

confidence: 99%

Synthesis of a Water‐Soluble Pyrazole Curcumin Derivative: In Vitro and In Vivo AGE Inhibitory Activity and Its Mechanism

et al. 2017

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“…A series of novel CUR bisacetamides have been synthesized for enriching their biological activities such as in vitro antioxidant, anti-inflammatory and cytotoxic activities. All the compounds exhibited potent to good anti-inflammatory, antioxidant and significant cytotoxic activities 136 . Three series of dimethylamino curcuminoids viz.…”

Section: Biological Activities Of Various Curcuminoid Formulationsmentioning

confidence: 99%

Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives – A review

Amalraj¹,

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Gopi

et al. 2017

Journal of Traditional and Complementary Medicine

631

355

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In recent years, several drugs have been developed deriving from traditional products and current drug research is actively investigating the possible therapeutic roles of many Ayruvedic and Traditional Indian medicinal therapies. Among those being investigated is Turmeric. Its most important active ingredient is curcuminoids. Curcuminoids are phenolic compounds commonly used as a spice, pigment and additive also utilized as a therapeutic agent used in several foods. Comprehensive research over the last century has revealed several important functions of curcuminoids. Various preclinical cell culture and animals studies suggest that curcuminoids have extensive biological activity as an antioxidant, neuroprotective, antitumor, anti-inflammatory, anti-acidogenic, radioprotective and arthritis. Different clinical trials also suggest a potential therapeutic role for curcuminoids in numerous chronic diseases such as colon cancer, lung cancer, breast cancer, inflammatory bowel diseases. The aim of this review is to summarize the chemistry, analog, metal complex, formulations of curcuminoids and their biological activities.

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“…Anti-inflammatory studies [29] All the newly synthesized 1,2,3-triazolyl-1,4-dihydropyridine hybrids were screened for anti-inflammatory activity by using the inhibition of albumin denaturation technique with minor modification. The standard drug and synthesized compounds were dissolved in a minimum quantity of dimethyl formamide (DMF) and diluted with phosphate buffer (0.2 M, pH 7.4).…”

Section: Antibacterial Studiesmentioning

confidence: 99%

Water mediated one-pot synthesis and biological evaluation of 1,2,3-triazolyl-1,4-dihydropyridine hybrids

et al. 2016

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Design and synthesis of a new series of 1,2,3-triazolyl-1,4-dihydropyridine hybrids (5a-5l) have been accomplished by a one-pot multicomponent reaction of opropargyl salicylaldehyde/o-propargyl naphthaldehyde, b-keto compounds, ammonium acetate, and organic azides in short reaction times. In vitro antibacterial studies of the newly synthesized hybrids were investigated against four different human pathogens, viz. S. aureus, Proteus mirabilis, E. Coli, and K. Pnemonia, and the results were compared with that of the standard drug, tetracycline. Also, their anti-inflammatory activity was studied against bovine serum albumin (BSA) and compared with that of the reference drug, dichlofenac. Some of the hybrids show good antibacterial and antiinflammatory activities comparable with that of the reference drugs.Electronic supplementary material The online version of this article (

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Synthesis and biological evaluation of new symmetric curcumin derivatives

Cited by 49 publications

References 23 publications

Synthesis of a Water‐Soluble Pyrazole Curcumin Derivative: In Vitro and In Vivo AGE Inhibitory Activity and Its Mechanism

Synthesis of a Water‐Soluble Pyrazole Curcumin Derivative: In Vitro and In Vivo AGE Inhibitory Activity and Its Mechanism

Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives – A review

Water mediated one-pot synthesis and biological evaluation of 1,2,3-triazolyl-1,4-dihydropyridine hybrids

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