Synthesis and biological assessment of novel cyanopyridine derivatives

Convenient Synthesis of Binary and Fused Pyrazole Ring Systems: Accredited by Molecular Modeling and Biological Evaluation

“…The ease of formation of six-membered ring is less than for a sevenmembered one because the slight improvement in the strain factor is outweighed by deterioration in the distance factor. [17] The suggested mechanism of the last reaction for construct compound 6 was proceed via condensation reaction of hydrazine hydrate with DHA 1 formed hydrazone 6 A, followed by nucleophilic attack of free amino group to the more electrophilic carbon at lactonic carbonyl group afforded intermediate 6 B through fission which readily reacts further with a second molecule of hydrazine to afford fused pyrazole 6 (route A) (Scheme 3). Whereas, in the case of the using ethanol increases the electrophilicity of the ketonic carbonyl group at position 4 and makes it more susceptible to nucleophilic attack (route B) (Scheme 3).…”

“…The most acceptable explanation of this matter is the overall ease of ring closure may be derived from two factors: a monotonous decrease in the ease of having the ends of the ring meet and a strain factor, which becomes more favorable to closure as the ring size increases from three‐ to six‐membered. The ease of formation of six‐membered ring is less than for a seven‐membered one because the slight improvement in the strain factor is outweighed by deterioration in the distance factor [17] …”

Pharmacological Perspectives of 2‐alkoxy‐3‐Cyanopyridine Scaffolds: An Up‐to‐Date Review

“…Hashash et al reported the diphenyl-substituted cyanopyridine derivatives 38 a-k (Figure 10) and tested them against Gram(À ) and Gram(+) bacterial strains to assess their antibacterial activity. [87] According to the findings, chemicals 38 a and 38 b had the most efficacy against Escherichia coli. The activity H.A.Eldeab synthesized a series of substituted pyridyl 4chlorobenzoates derivatives 39 a-q(Figure 10) by microwave method.…”

“…Hashash et al . reported the diphenyl‐substituted cyanopyridine derivatives 38 a – k (Figure 10) and tested them against Gram(−) and Gram(+) bacterial strains to assess their antibacterial activity [87] . According to the findings, chemicals 38 a and 38 b had the most efficacy against Escherichia coli.…”

Nicotinonitrile as an essential scaffold in medicinal chemistry: an updated review (2015– present)

“…Pyridine derivatives containing p-dimethylaminophenyl and pbromophenyl moieties at positions 4 and 6 were synthesized and the findings revealed that compound 47 had the highest activity against Gram-negative bacteria (Escherichia coli) and moderate activity against Gram-positive bacteria (Staphylococcus aureus) (Fig. 15) [86]. The antibacterial activity of the synthesized 1,2,3-triazole-linked nicotinonitriles 48 was investigated, and compounds 48a and 48b had the highest activity against Gram-positive bacteria S. aureus with MIC= 17.6 and 16.8 g/mL, respectively.…”