Synthesis and biological activity of 1,3-di(3-dimethoxyphosphorylpropyl) derivatives of uracil and 6-methyluracil

Design, Synthesis, Antiviral, and Cytostatic Evaluation of Novel Isoxazolidine Analogs of Homonucleotides

“…All N ‐allylated nucleobases 15 , except for 15r , have already been described in the literature . For the purpose of this study, they were prepared by allylation of commercially available nucleobases employing four different protocols (Scheme ; for the list of applied nucleobases ( B ) see Table ).…”

“…Compounds 15a and 15b , 15c and 15d , 15f , 15g , 15h,i , 15n – q , and 15r were prepared following the literature procedures using allyl bromide and potassium carbonate in DMF (Scheme , method a) . N ‐Allylpyridinones 15h and 15i were successfully prepared in the same manner to avoid formation of O ‐allylated by‐products reported as a major problem in the application of a PTC approach .…”

Synthesis and antimicrobial activity of 3-methyl-substituted 6,8-dimethylthiazolo-[2,3-f]xanthines

“…Previously, we reported on the synthesis of 3-methylsubstituted thiazoloazoles, which exhibited antiulcerogenic [1], iummunomodulating [2,3], antiinflammatory, and antiaggregant activity [4]. In continuation of the search for biologically active compounds, we have synthesized a series of new 3-methyl-substituted thiazoloazoles proceeding from 3-chloromethyl-6,8-dimethylthiazolo [2,3-f]xanthine (I) and studied the antimicrobial properties of isolated products.…”

Microwave-assisted N-allylation of uracil and thymine pyrimidine bases

“…Most of them are concerned with N-alkylation by using sodium hydroxide in acetone [15], inorganic catalysts, e.g., iodine in 1,2-dichloroethane [16], sodium hydride [19], or potassium carbonate in DMF [14,20]. Usually, in order to obtain significant reaction yields, these procedures require temperatures above 80 o C, which produces side reactions, mainly thermal decomposition.…”