Synthesis and biological activity of N-(β-arylethyl)amidines and N,N′-bis(β-arylethyl)amidines

Marchenko, N. B.; Граник, В. Г.; Глушков, Р. Г.; Budanova, L. I.; Kuzovkin, V. A.; Паршин, В. А.; Al'tshuler, R. A.

doi:10.1007/bf00758088

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Synthetic Antiamoebic Compounds1

Amidines1

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2009

2015

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Cited by 2 publications

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“…Amidines display a large variety of biological properties − and are utilized as precursors in many heterocyclic syntheses. − Metal complexes of amidines with a 1,2,4-triazole ring display low-temperature molecular ferromagnetics . Further bicyclic amidines have been identified as highly active acylation catalysts .…”

Section: Synthetic Antiamoebic Compoundsmentioning

confidence: 99%

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Chemistry and Biology of Synthetic and Naturally Occurring Antiamoebic Agents

2009

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Section: Synthetic Antiamoebic Compoundsmentioning

confidence: 99%

“…Amidinesdisplayalargevarietyofbiologicalproperties [188][189][190][191] andareutilizedasprecursorsinmanyheterocyclicsyntheses. [192][193][194][195] Metal complexes of amidines with a 1,2,4-triazole ring display low-temperature molecular ferromagnetics.…”

Section: Amidinesmentioning

confidence: 99%

Chemistry and Biology of Synthetic and Naturally Occurring Antiamoebic Agents

2009

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Biological evaluation of inhibitors of reverse transcriptase from HIV type-1

Lautre¹,

Hadda²,

Das³

et al. 2015

10.5267/j.ccl

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In the present work, Zn(II), Co(II) and Cr(II) metal complexes (3-5) of N-hydroxy-4-[(hydroxyimino)methyl]benzamidine ligand (2) were synthesized and their anti-HIV activity by inhibiting reverse transcriptase was explored. Structural characterization using NMR, FTIR, Mass, UV-Vis spectra, TGA, magnetic moment and elemental analyses were performed. The analyses show that geometry, lipophilicity and steric factor play crucial role. Cell viability test is performed on peripheral blood mononuclear cells to check toxicity of prepared compounds on immune system, shows toxicity only at higher concentration. Antimicrobial activity and DNA cleavage analysis have also been studied and reported.

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Synthesis and biological activity of N-(β-arylethyl)amidines and N,N′-bis(β-arylethyl)amidines

Cited by 2 publications

References 2 publications

Chemistry and Biology of Synthetic and Naturally Occurring Antiamoebic Agents

Chemistry and Biology of Synthetic and Naturally Occurring Antiamoebic Agents

Biological evaluation of inhibitors of reverse transcriptase from HIV type-1

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