Abstract:The substituted warfarin acid chalcones have been prepared by condensation of warfarin acid and aromatic/aliphatic aldehyde using aq. NaOH as catalyst. The method is simple, cost-effective and gives good yield in a short reaction time. All the compounds synthesized have been characterized by IR, NMR and Mass spectra. A new series of 4-hydroxy-3-(3-oxo-1,5-diaryl-3-oxo-pent-4-enyl)-chromen-2-ones were synthesized and submitted to biological activity. Result of the biological screening showed the compounds 3b, 3… Show more
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