Synthesis and Biological Activity of New Derivatives of 3-(3,4-Diaryl-1,2,4-triazole-5-yl)propenoic Acid.

Abstract

Acid. -Among a variety of title compounds the derivative (IIIb) shows antinociceptive and anticonvulsive activity. -(MODZELEWSKA-BANACHIEWICZ*, B.; BANACHIEWICZ, J.; CHODKOWSKA, A.; JAGIELLO-WOJTOWICZ, E.; MAZUR, L.; Eur.

Does dehydrocyclization of 4-benzoylthiosemicarbazides in acetic acid lead to s-triazoles or thiadiazoles?

“…The triazole-and thiadiazole-based compounds have been reported as antimicrobials , antivirals [22][23][24], antitumors [6,10,[25][26][27][28][29][30][31], anticonvulsants [11,32,33] antidepressants [34][35][36], analgesic [8,[37][38][39][40][41] and anti-inflammatory [8,9,37,38,[42][43][44][45][46] agents. An excellent strategy for the synthesis of these azoles is the dehydrocyclization of 1,4-disubstituted thiosemicarbazides.…”

The determination of the stability constants of complexes of 1,2,4-triazoles and biologically relevant ligands with M(II) by potentiometric titration in aqueous solution

“…1,2,4-Triazole (1,2,4-TRZ) and its derivatives constitute a promising class of ligands that are widely used in the synthesis of various complexes [11]. Complexes of triazoles play a significant role in biological processes [12][13][14][15], such as anti-inflammatory, antimycobacterials [16], and anticonvulsants [17]. Metal complexes of triazoles are used to produce pharmaceutical compounds to inhibit tumor growth and cancer in mammals [18][19][20][21].…”

New thiazolidinedione-5-acetic acid amide derivatives: synthesis, characterization and investigation of antimicrobial and cytotoxic properties

“…These drugs may also be beneficial in multiple sclerosis and neurodegenerative diseases, including Alzheimer's and Parkinson's at least partially due to their anti-inflammatory activity (Heneka and Landreth, 2007). On the other hand, thiadiazole nucleus constitutes the active part of several biological active compounds, including antibacterial, antifungal (Modzelewska-Banachiewicz et al, 2004;Foroumadi et al, 2005a;Kadi et al, 2007), antitubercular (Solak and Rollas, 2006;Mamolo et al, 2003;Foroumadi et al, 2005c), analgesic (Schenone et al, 2006), anti-inflammatory (Farghaly et al, 2000;Kadi et al, 2007;Schenone et al, 2006), antidepressant (Varvaresou et al, 1998), leishmanicidal (Foroumadi et al, 2005b) agents. In view of these facts, we have designed and synthesised a number 2-(2,4-dioxo-1,3-thiazolidin-5-yl)-N-(5-substituted-1,3,4-thiadiazol-2-yl)acetamide derivatives.…”