Synthesis and biological activity of some pyrimidine derivatives

Synthesis and characterization of new complexes derived from 4-thienyl substituted pyrimidines

“…This group of ligands includes the family of pyrimidines, which are known to have a great value in medicinal chemistry due to a variety of biological activity, ranging from antituberculosis [2], antiviral [3], antitumor [4], immunosuppressive [5], anticonvulsant to antioxidant [6] activities. Also, the excellent fluorescence properties of pyrimidines can be achieved by functionalization of the pyrimidine ring with phenylamine, carbazole, 2-phenylthiophene and 2,2'-bithiophene units [7], [8].…”

Synthesis, Structural Elucidation of Novel Thieno [2,3-d] Pyrimidine Core Unit Containing 1,2,4-Triazoles and Thiophenes as Potent Antimicrobial Activity

“…THF was distilled from sodium benzo phenone ketyl and degassed thoroughly with dry argon directly before use. Unless otherwise noted, organic extracts were dried with anhydrous Na 2 SO 4 , filtered through a fitted glass funnel, and concentrated with a rotary evaporator (20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30). Flash chromatography was performed with silica gel (200-300 mesh) by using the mobile phase indicated.…”

“…In the present work, the starting thieno [2,3-d]pyrimidine-2,4-diol(2) was prepared from methyl 2-amino thiophene-3-carboxylate (1) and Urea was prepared according to synthetic procedure [27]. 2,4-dichlorothieno[2,3-d]pyrimidine (3) was prepared according to synthetic procedure [28].…”

Green Expedient Synthesis of Pyrimidine Derivatives via Chalcones and Evaluation of their Anthelmintic Activity

“…[10][11][12] Numerous methods have been reported to prepare pyrimidine derivatives. 13,14 However, these reported methods suffered from drawbacks such as longer reaction time, complicated work up procedures, use of acids or bases and hazardous solvents. 15,16 Thus, the use of microwave energy for the synthesis of new drug molecules follows green chemistry approach.…”