Synthesis and biological activity of acetylkarfedon

Прокопов, А. А.; Sukhanova, S. A.; Berlyand, A. S.; Spektor, S. S.; Kalosha, V. I.; Robakidze, T. N.; Knizhnik, A. Z.

doi:10.1007/bf00780203

Cited by 1 publication

(2 citation statements)

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“…Carphedon [(2-oxo-4-phenylpyrroline)acetamide] was synthesized in Russia at the beginning of the 1990s. [1][2][3][4][5] It is a phenylethylamide derivative chemically related to nootropil as well as an analogue of pemoline and is described as a psycho stimulant and stress protector. Several members of these classes possess analgesic properties, which are comparable to that of morphine.…”

Section: Introductionmentioning

confidence: 99%

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Determination of carphedon in human urine by solid-phase microextraction using capillary gas chromatography with nitrogen–phosphorus detection

Kim¹,

Park²,

Myung³

et al. 1999

Analyst

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Carphedon is a phenyl derivative of nootropil and is effective in increasing physical endurance and cold resistance, and is used for amnesia treatment. Carphedon was extracted from human urine samples by solid-phase microextraction with a 65 microns carbowax-divinylbenzene-coated fiber. This analysis was performed by using capillary gas chromatography with nitrogen-phosphorus detection and optimized at pH 9.6, 30% NaCl, immersion time 10 min and desorption in the GC injector at 250 degrees C for 3 min. The regression equation for carphedon showed good linearity in the range from 0.1 to 10 micrograms ml-1 for human urine samples. The limit of detection was 0.01 microgram ml-1. The developed method is more sensitive and simpler in sample preparation than liquid-liquid extraction and can be applied to doping analysis for stimulants.

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Section: Introductionmentioning

confidence: 99%

“…Fig 5. Capillary GC-NPD chromatograms for the SPME extracts of human urine samples taken at 18 h after ingestion of a tablet.…”

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confidence: 99%