Synthesis and Biological Activity of Novel Acyclic Versions of Neplanocin A.

Abstract

Nucleic acids U 0700Synthesis and Biological Activity of Novel Acyclic Versions of Neplanocin A. -A simple synthetic method for novel acyclic Neplanocin A analogues (VIII) is developed. The compounds are tested for their antiviral and antitumor effects. (VIII) exhibit toxicity non-related to any anti-HIV-1 activity. -(WU, Y.; HONG*, J. H.; Arch.