Synthesis and biological activity of derivatives of thiazolidine-4-carboxylic acid and thiazolidino[3,4-a]piperazine-5,8-dione

New Heterofused Thiazolo/Pyrazinedione Hybrids as Promising Building Blocks for Anticancer Drug Development: Synthesis, Biological and Drug‐Likeness Evaluation

“…[25] As a consequence, some heterocycles such as thiazolidine and dioxopiperazine can be fused into derivatives with potential biological activity. [26] These compounds have been studied for their potential in the treatment of hypertension [27] and also, because of their immunoregulatory activity on human T lymphocytes, with similar performance to the well-known drug Levamisole® (Figure 1). Therefore, the synthesis of those derivatives is a promising new field of research.…”

A Novel and Convenient Synthesis of Thiazol-2(3H)-imine-Linked Glyco­conjugates

“…In recent years, thiazolidene and its derivatives have received considerable attention because of their bioactivity and many applications in organic and medicinal chemistry. [1][2][3][4][5][6] For example, Masuda's group has reported that a series of thiazolidenebenzenesulfonamide derivatives are a novel class of non-nucleoside HIV-1RT inhibitors. 2,3 Therefore, the preparation of these compounds has become increasingly important.…”

Synthesis and biological characterization of new N-acyl-thiazolidine-4-carboxylic acid derivatives

“…Previously, we have established [3] that bicyclic thiazolinopiperazines (I) can also be split in aqueous media with the formation of mercaptomethylpiperazinediones (I).…”

“…Taking into account that the hydrolytic transformation of thiazolidine-4-carboxylic acids leads to substituted cysteines (III) [3,4], which are known as inhibitors of kinase II (angiotensin converting enzyme, ACE) [5,6], such compounds can be of interest in obtaining new antihypertensive agents [7 -9].…”