Synthesis and Biological Activity of Triazole Analogues of Piperazine

Synthesis and biological evaluation of pyrazole analogues linked with 1,2,3-triazole and 4-thiazolidinone as antimicrobial agents

“…The reaction of phenylazide 1 with acetylacetone in the presence of anhydrous potassium carbonate in dimethylfomamide under stirring at reflux temperature 6-12 hours, afforded 1-(5-methyl-1-phenyl-1H-1,2,3-triazol-4-yl)-1-ethanone 2 in (2.39 g, 0.012 mol) 81% of yield 40 , which on condensation with phenyl hydrazine hydrochloride in the presence of sodium acetate and in water under stirring at room temperature for 4 hours, furnished the 1-(5-methyl-1-phenyl-1H-1,2,3-triazol-4-yl)-1-ethanone-1-phenyl hydrazone 3 in (2.32 g, 0.008 mol) 74% of yield 41 . The compounds 3 was treated with formyl solution (N,N-dimethylformamide and phosphorous oxychloride) under stirring at 55 o C for 6 hours to afford the 3-(5-methyl-1-phenyl-1H-1,2,3-triazol-4-yl)-1-phenyl-1H-4-pyrazolecarbaldehyde 4 in (2.3 g, 0.007 mol) 69% of yield 41 .…”