Synthesis and biological activity of 2-chloro-3-formyl-1,8-naphthyridine chalcone derivative

Ayoob, Alaa I.; Yahya, Omar; Saleh, Mohanad; Chemistry, Conference

doi:10.21608/ejchem.2022.134661.5925

Cited by 3 publications

(2 citation statements)

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“…Spectra data is shown in Table (3) infrared spectrum and Table ( 4) nuclear magnetic resonance Also, Synthesis compound (6) [bis(O-methoxy benzylidine imine)] contains two Imine groups, which are similar in composition to the dienes structure. Hydrazine hydrate (80%) was used to prepare this compound with a ratio of 1 mol from hydrazine to 2 moles of benzaldehyde substitutes, and acetic acid was used as a catalyst to complete the reaction (25)(26)(27) . This compound was characterized by the following main absorption bands of IR (7)(8)(9)(10)(11) the di-imine compounds were reacted with Schiff bases in a reaction similar to the reactions of Diels-Aldur, where the substitutes for the Schiff bases (1-5) as dinofyl and the diamine compound (6) as diene (23) by reflux was used benzene as a solvent, the mechanism suggestion shown in figure (2) .…”

Section: Resultsmentioning

confidence: 99%

Synthesis and Biological Evolution of Novel Substituted 1,2,4-triazine from Sulfanilic Acid

Saeed

Saleh

Sadeek³

2023

Egypt. J. Chem.

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In this paper, a new series of substituted 1, 2,4-triazines was prepared by reacting 4-amino sulfanilic acid with substituted benzaldehyde to form the corresponding Schiff base compounds (1-5), and then reacting two moles of O-methoxy benzaldehyde with hydrazine to form a compound ( 6) and these compounds reacted with Schiff base (1-5) by applying the Diels-alder reaction in the presence of benzene as a solvent and refluxed it to cyclized into substituted of 1,2,4-triazines derivatives (7-11). Depending on the physical and spectroscopic properties of the prepared compounds that were identified, infrared spectroscopy and nuclear magnetic resonance were used. An evaluation of the biological activity of the prepared compounds was conducted and it gave anti-bacterial results, such as gram-positive and gram-negative when compared with known antibiotics.

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Section: Resultsmentioning

confidence: 99%

Synthesis and Biological Evolution of Novel Substituted 1,2,4-triazine from Sulfanilic Acid

Saeed

Saleh

Sadeek³

2023

Egypt. J. Chem.

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“…Antibacterial activity of new complexes is subjected on Escherichia coli, Pseudomonas aeruginosa via using disc diffusion method in DMSO. [27][28][29]The results are listed in table 7. Role of negative results are effective so, all new complexes exhibited no activity against Escherichia coli, Pseudomonas aeruginosa except complex 2a,d .…”

Section: Antibacterial Activitymentioning

confidence: 99%

Preparation of New Complexes of Bivalent Manganese, Iron, Cobalt, and Nickel with Mixed Ligands of Ciprofloxacin (Cip) and Metronidazole (Met) or 4-Aminoantipyrine (4AAP) with Study of Their Chemical, Physical Properties and Antibacterial Activity

et al. 2022

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Synthesis of mixed metal complexes were done through reaction of two drugs such as antipyrine, or ciprofloxacin with Metronidazole to have eight complexes. Physical, chemical and antibacterial activity of new complexes were studied. These mixed ligands were further coordinating with bivalent transition metals in a metal: ligands mixture ratio 1:1. These complexes were characterized by using elemental analysis and physical properties, in addition molar conductance in DMF which showed non-electrolytic behavior. FT-IR spectra revealed absorption bands for new ligands and metal complexes that agreed with the propose structures and the electronic spectra verified that these complexes display six-coordinate octahedral geometry. Antibacterial activity showed good results.

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Synthesis and Pharmacological Profile of Hydrazide Compounds

Sadeek

Saeed

Saleh

2023

RJPT

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This class of compounds, which is known as Hydrazide has great significance in organic chemistry. This is the reason why methods of preparation of different types of compounds that are useful in many fields are studied here. It is characterized by containing an active group, which is (-CONHNH2), which consists of two nitrogen atoms attached to four substitutes, and at least one of these substitutes must be an (acyl) or (aryl) group. It is known that these compounds have very important medical, pharmaceutical and industrial functions and applications. Some of them have been employed in the treatment of many common and dangerous diseases, such as respiratory diseases and malaria. In addition, they are highly useful in preparing some important drugs used in the treatment of some chronic diseases related to blood vessels and muscle spasms, showing a wide variety of biological activities, including antibacterial, mitigating, anticonvulsant, antiviral, and antiprotozoal activity. Moreover, they may be used as raw materials in preparing many classes of heterocyclic compounds, including oxadiazole and diazole compounds. Finally, they show significance in industrial applications, particularly in the manufacture of dyes, agricultural pesticides, and growth stimulants for plants and Agricultural crops.

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Synthesis and biological activity of 2-chloro-3-formyl-1,8-naphthyridine chalcone derivative

Cited by 3 publications

References 0 publications

Synthesis and Biological Evolution of Novel Substituted 1,2,4-triazine from Sulfanilic Acid

Synthesis and Biological Evolution of Novel Substituted 1,2,4-triazine from Sulfanilic Acid

Preparation of New Complexes of Bivalent Manganese, Iron, Cobalt, and Nickel with Mixed Ligands of Ciprofloxacin (Cip) and Metronidazole (Met) or 4-Aminoantipyrine (4AAP) with Study of Their Chemical, Physical Properties and Antibacterial Activity

Synthesis and Pharmacological Profile of Hydrazide Compounds

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