Synthesis and biological activity of new pyranochromen-3-carboxamides

Shutov, Roman V.; Kuklina, E. V.; Anisimova, N. A.; Anan’ev, E. P.; Kotova, N. I.; Kuklin, V. N.

doi:10.1007/s11094-012-0725-0

Cited by 2 publications

(1 citation statement)

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“…The presence of benzimidazole pharmacophore in the various branches of medical science is inexplicable. The therapeutic uses of benzimidazole include anticancer [15][16][17][18][19][20], antimicrobial [21][22][23][24], antiparasitic [25,26], antiinflammatory and analgesics [27][28][29], antiviral [30][31][32], and antiulcerative [33] activities and in fields like ophthalmology, neurology, endocrinology, etc. The first example of a benzimidazole that was clinically available was thiabendazole (2), which can be used as a fungicide and for antiparasitic purposes [34].…”

Section: Introductionmentioning

confidence: 99%

Exploring the Versatility of Benzimidazole Scaffolds as Medicinal Agents: A Brief Update

Kavya¹,

Sivan²

2022

Benzimidazole

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Benzimidazole, one of the finest classes of heterocyclic aromatic compounds have the characteristic structure of benzene fused with a five-membered imidazole ring. Despite being made their first appearance in the late 1870s, they are considered as a ‘privileged molecule’. The applications of this wonder molecule range from medicinal chemistry to material science. Benzimidazole being a potent inhibitor for various enzymes has got therapeutic effects like anticancer, antimicrobial, anthelmintic, antioxidant, anticonvulsant, antifungal, anti-inflammatory, antiviral, antihistaminic, antipsychotic, etc. It has also made its existence in various branches of medical science viz ophthalmology, neurology, cardiology and more. The applications of benzimidazole are not only limited to the biological field but also expanded to the field of material chemistry as well. This chapter summarizes the pharmacological properties of benzimidazole, illustrated on numerous derivatives since 2016.

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