Synthesis and biological activity of derivatives of 4,8-dioxo-3,4,5,6,7,8-hexahydrobenzothieno[2,3-d]pyrimidine

Crystal structure of ethyl 2-phenyl-4-(prop-2-yn-1-yloxy)-5,6,7,8-tetrahydropyrido[4′,3′:4,5]thieno[2,3-d]pyrimidine-7-carboxylate

“…For the diversity of biological activities of thieno-pyrimidine derivatives, see : Nasr & Gineinah (2002); Bhuiyan et al (2005); Chambhare et al (2003); Alagarsamy et al (2006). Kapustina et al (1992). For related structures, see: Liu et al (2005); Ren et al (2006 Table 1 Hydrogen-bond geometry (Å , ).…”

“…Thieno[2,3-d]pyrimidines are a large group of heterocyclic compounds (Litvinov, 2004), and some of them showed antiviral (Nasr & Gineinah, 2002), antimicrobial (Bhuiyan et al, 2005;Chambhare et al, 2003), and antibacterial properties (Alagarsamy et al, 2006). Fused tri-and tetracyclic thieno[2,3-d]pyrimidin-4-ones are synthesized by many methods and among them some compounds have fungicidal, antibacterial, and anti-inflammatory activities (Kapustina et al, 1992). In this context, and following to our on-going study of bio-active molecules, we report here the synthesis and crystal structure of the title compound.…”

9-Furfurylidene-2,3-dimethyl-6,7,8,9-tetrahydro-4H-thieno[2′,3′:4,5]pyrimidino[1,2-a]pyridin-4-one

“…For the synthesis of thieno[2,3-d]pyrimidin-4-ones and their derivatives, see: Melik-Ogandzhanyan et al (1985); Csukonyi et al (1986); Shvedov et al (1975); Shakhidoyatov (1983); Gevald et al (1966); Kapustina et al (1992); Peet et al (1986); Shodiyev et al (1993); Bozorov et al (2009). For the physiological activity of thieno[2,3-d]pyrimidin-4-ones and their derivatives, see: Kapustina et al (1992); Blaskiewich et al (1975); Wä hä la et al (2005); Lilienkampf et al (2007); Han et al (2007); Moore et al (2006). For weak hydrogen bonds in alkaloids, see: Rajnikant et al (2005).…”

Thieno[2,3-d]pyrimidin-4-ones 1. Condensation of 2,3-dimethyl- and 2,3-tri-, 2,3-tetra-, and 2,3-pentamethylene-7,8-dihydro-pyrrolo[1,2-a]thieno[2,3-d]pyriminidin-4(6H)-ones with aromatic aldehydes and furfural

“…They are traditionally synthesized from 2-amino-3-ethoxycarbonyl-4,5-disubstituted thiophenes by condensation with lactams [10,11] or O-alkyl esters of lactams [3], and also from cyclic ketones by the Gewald reaction [12,13]. Oxidation [14,15] and formylation [16,17] of such compounds occurs exclusively at the CH 2 group of ring A connected with the heterocyclic system of rings B and C at position 2.…”

“…At the same time, among them are known substances which possess various biological activities (fungicidal, bactericidal, anti-inflammatory, etc.) [3][4][5][6][7][8][9], which shows potential for further synthesis and the study of properties of substances with similar structures.…”