Synthesis and biological activity of bisiodomethylates of amino esters of sym-triazine-containing dicarboxylic acids

Antonyan, S. G.; Zaplishnyi, V. N.; Pogosyan, G. M.; Libinzon, R.E.; Lavretskaya, É. F.; Pyzhov, V. K.; Bessudnova, N. V.; Sarkisyan, D.; Vatolkina, O. E.

doi:10.1007/bf00766902

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2010

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“…Furthermore, 1,3,5-triazine derivatives posses a wide variety of biological activity as HIV treatment, and as catalysts, herbicides, carcenolytics [17][18][19][20], as well as compounds with growth-stimulating activity, antidote activity, nontoxic cationic surfactants, and inhibitors of the oil oxidizing processes [21][22][23][24][25][26][27][28].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of new 4,6-disubstituted-1,3-5-triazin-2-yloxy esters and N-hydroxyamides

et al. 2010

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A convenient method for synthesis of new sym-triazine ester and hydroxamate derivatives has been developed. Various reaction conditions were studied and optimized, and a series of new 1,3,5-triazine based esters and N-hydroxyamides were obtained with good yields (38-80%). The reaction between oxo-derivatives of 4,6-disubstituted-1,3,5-triazines and halogenated carboxylic esters derivatives using Cs2CO3 as a catalyst was found to be the most convenient method for 4,6-disubstituted-1,3,5-triazine-2-yloxy esters synthesis. These 1,3,5-triazin based esters served as precursors for the synthesis of 4,6-disubstituted-1,3,5-triazin-2-yloxy-N-hydroxybutanamides using solution of hydroxylamine hydrochloride in dry methanol and KOH at room temperature. Structures of the newly synthesized compounds were obtained by 1 H NMR, 13 C NMR, MS, IR spectral data and elemental analysis.

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