Synthesis and biological activity of novel N-cycloalkyl-(cycloalkylaryl)-2-[(3-R-2-oxo-2H-[1,2,4]triazino[2,3-c]quinazoline-6-yl)thio]acetamides

Synthesis and antiviral activity of [(9-R1-10-R2-3-R-2-oxo-2H-[1,2,4]-triazino[2,3-c]quinazolin-6-yl)thio]acetamides derivatives with the fragments of carcass amines

“…IR spectra (4000-600 cm -1 ) were recorded on a Bruker ALPHA FT-IR spectrometer (Bruker Bioscience, Germany) using a module for measuring attenuated total reflection (ATR). Substances 1.1-1.12 and 2.1-2.7 were synthesized according to the reported procedures [16,17]. Other starting materials and solvents were obtained from commercially available sources and used without additional purification.…”

“…The antiviral activity of substances 3.1-3.19 was determined against respiratory viruses using standard AACF screening assay protocols [16][17]. The research was conducted on the most virulent and pathogenic strains for human Flu A H1N1, Flu A H5N1, Flu A H3N2 and less genetically various strain Flu B.…”

Synthesis and Hypolipidemic Activity of New 6,6‐Disubstituted 3‐R‐6,7‐Dihydro‐2H‐[1,2,4]triazino[2,3‐c]quinazolin‐2‐Ones

“…Considering this fact, strategy of creation of new drugs may involve the synthesis of compounds with the affinity to the molecular target or an empirical search of substances with lipid-lowering activity with the following establishment of the mechanism of action for aimed chemical modification. Thus, the purpose of this study is to find lipid-lowering drugs among the original unexplored 6,6-disubstituted 3-R-6,7-dihydro-2H- [1,2,4] triazino [2,3-c]quinazolin-2-ones, which combine in their structure «pharmacophore» fragment [20,21] and lipophilic aliphatic and aromatic substituents.…”

Utility of 2-Methyl-quinazolin-4(3H)-one in the Synthesis of Heterocyclic Compounds with Anticancer Activity

“…In addition to a deuterium oxide exchangeable singlet at δ 10.68 ppm attributed to NH proton. Moreover, a group of Slovak's scientists reported that [1,2,4]triazolo [4,3-c]quinazoline derivatives possess considerable in vitro antitumor activity [46]. So we synthesized [1,2,4]triazolo [4,3-c]quinazoline compound 24 through the cyclization of the Schiff's base 21 in glacial acetic acid/sodium acetate.…”

“…Recently, several biological activities have been reported for [1,2,4]triazino [4,3-c]quinazolines [46], so our aim was extended to the development of different synthetic methods for novel [1,2,4]triazino [4,3-c]quinazolines 17 and 18 and investigation of their cytotoxicity and antitumor activity "(Scheme 5)". Therefore, condensation of compound 9 with benzoin and with chloroacetyl chloride were applied to furnish the target compounds 17 and 18; respectively.…”