Synthesis and biological activity of 7,8-polymethylenepurines

Molecular modeling study bioactive natural product of khellin analogues as a novel potential pharmacophore of EGFR inhibitors

“…In the 31 1 H NMR data, which is consistent with the data in concerning a study of the spectra for such compounds 52 . The tendency of 1,3,2-diazaphosphorin derivatives to form pyridine solvates of variable composition has been described [53][54][55][56][57] . We carried out an analogous cyclization within this work based on 1,2-trimethylene-4-amino-5-cyanoimidazole 58,59 .…”

Synthesis of Fused 9,10‐Dihydro‐6H‐Azepino‐ and 9,10‐Dihydro‐6H‐[1,3]Diazepino[1,2‐e]Purines via Ring Closing Metathesis as Antilipid Peroxidation Agents

“…Fused purine derivatives also display a wide range of biological effects, that is, anti‐inflammatory, antihypertensive, anxiolytic, cytostatic, antimicrobial, antiviral, and vasodilation activity . Fused azepinopurines have been examined for their antiviral and antitumor activity . Fused diazepinopurines have been found to present cytotoxic , anticonvulsant , CNS stimulating activity .…”

“…Four different strategies have been applied for the preparation of cyclonucleosides and the fused purine derivatives . The first method involves the radical or ionic cyclization of substituted purines.…”

“…The second method starts from a functionalized pyrimidine where the imidazole ring is formed by a cyclocondensation . The third method involves construction of the pyrimidine ring by heterocyclization of an appropriately substituted fused imidazole derivative . In the fourth method, more recently, the ring closing metathesis (RCM) was used from the appropriate diolefinic substituted precursors [21c,27,28].…”