Synthesis and biological activity of olomoucine II

Kryštof, Vladimı́r; Lenobel, René; Havlı́cěk, Libor; Kuzma, Marek; Strnad, Miroslav

doi:10.1016/s0960-894x(02)00693-5

Cited by 65 publications

(57 citation statements)

References 15 publications

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“…The first synthetic purine inhibitor of CDKI was Olomoucin (Hajduch et al 1999;Kryštof et al 2002). The development of new pharmaceuticals has inevitably involved studies of their toxicity.…”

Section: Discussionmentioning

confidence: 99%

Use of the Crustacean Artemia franciscana for Alternative Biotests

et al. 2010

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Use of the crustacean Artemia franciscana for alternative biotests of the second generation was studied, and possible experimental design and applications of such tests outlined. In addition to the classical use in ecotoxicology, the test can be used in pharmacology as well, or to monitor the effects of ionizing radiation in co-exposure with some chemical compounds. The synergistic effect of co-exposure of PCB (DELOR 103), cadmium chloride and potassium dichromate with beta 89 Sr irradiation was shown. We also demonstrated the anti-oxidative and pro-oxidative effects of the ascorbic acid in dependence on its concentration. Use of the pharmaco-toxicological screening in search for the novel inhibitors of cyclin-dependent kinases was demonstrated as well, showing that Artemia franciscana may be used as a suitable biosensor instead of the expensive tests on higher vertebrates.

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Section: Discussionmentioning

confidence: 99%

Use of the Crustacean Artemia franciscana for Alternative Biotests

et al. 2010

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“…It has been shown to have in vitro anticancer activity against a panel of tumour cell lines. 371,372 Storage / Stability: Stable if stored at -20°C, under desiccating conditions. Under these conditions, the product can be stored for up to 12 months.…”

Section: Iupacmentioning

confidence: 99%

A Compendium of Tyrosine-kinase Inhibitors: Powerful and Efficient Drugs against Cancer

Costa¹,

Forezi²,

Cardoso³

et al. 2017

Rev. Virtual Quim.

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Resumo: Os inibidores das enzimas tirosina quinases (ITQs), também conhecidos como tinibs , têm sido usados como fármacos mais modernos e eficazes no tratamento de diversos tipos de câncer. Este artigo é um compêndio de uma grande série de inibidores de tirosina quinase, recentemente aprovados ou que estão em fase de análise pelo FDA, contendo em cada um deles, relatos como: a primeira síntese química, linha de ação contra o câncer, fase clínica em que se encontram e o preço no mercado. Palavras-chave:Tinibs; tirosina-quinase; quimioterapia; testes clínicos; câncer. AbstractThe inhibitors of the enzymes tyrosine kinase (ITKs), also known by "tinibs", have been used as the most modern and effective tools in the treatment of several types of cancer. This article is a compilation of a huge series of tyrosine kinase inhibitors, recently approved or under clinical trials, containing in each of them information such as: the first chemical synthesis, the mechanism of action against cancer, clinical trials stage and price in the market.

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“…the glutamine pathway) (20,21,22,24). A proteomics study of the cellular effects of a related compound -olomoucine -demonstrated that antitumour effect of this class of compounds is mediated by several factors such as a decrease in protein synthesis and/or glycolysis which, in turn, diminishes the ability of cancer cells to survive and function (34,35,36).…”

Section: Fig 1 Chemical Structure Of R-roscovitine (2-(r)-(1-ethyl-mentioning

confidence: 99%

Cyclin-Dependent Kinases as Drug Targets for Cell Growth and Proliferation Disorders. A Role for Systems Biology Approach in Drug Development. Part I—Cyclin-Dependent Kinases as Drug Targets in Cancer

Idowu

2011

Biotechnology & Biotechnological Equipment

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Synthesis and biological activity of olomoucine II

Cited by 65 publications

References 15 publications

Use of the Crustacean Artemia franciscana for Alternative Biotests

Use of the Crustacean Artemia franciscana for Alternative Biotests

A Compendium of Tyrosine-kinase Inhibitors: Powerful and Efficient Drugs against Cancer

Cyclin-Dependent Kinases as Drug Targets for Cell Growth and Proliferation Disorders. A Role for Systems Biology Approach in Drug Development. Part I—Cyclin-Dependent Kinases as Drug Targets in Cancer

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