Synthesis and biological activities of 26-hydroxy-27-nor-derivatives of 1α,25-dihydroxyvitamin D3

The Centennial Collection of VDR Ligands: Metabolites, Analogs, Hybrids and Non-Secosteroidal Ligands

“…Figure 7 (1994-1997) [136][137][138][139][140][141][142][143][144][145][146][147][148]. Compounds 308 and 309 [147] present an interesting property by exhibiting only nongenomic rapid effects at physiological concentrations.…”

“…Compounds 225[93] and 208[108] were independently developed by different research groups and are important analogs functionalized at C-18 and C-11, respectively. They may allow the synthesis of haptens without disturbing the VDR ligand anchoring groups.Figure7(1994-1997)[136][137][138][139][140][141][142][143][144][145][146][147][148]. Compounds 308 and 309[147] present an interesting property by exhibiting only nongenomic rapid effects at physiological concentrations.…”

Apolipoprotein E (ApoE), a Bmp‐2 (bone morphogenetic protein) upregulated gene in mesenchymal progenitors (C3H10T1/2), is highly expressed in murine embryonic development

“…The murine fibroblastic C3H10T1/2 cell line which has originally been established from a mouse blastocyst [1] represents a relatively early stage of mesenchymal cell determination with the ability to differentiate into myoblasts, adipocytes, chondrocytes and osteoblasts [2][3][4]. This line is responsive to a variety of factors, cytokines, hormones and vitamines which regulate differentiation into the various lineages [5][6][7]. Therefore, this cell line harbours properties of an eternalized mesenchymal stem cell and, by now, is widely used for the analysis of factors initiating or modifying mesenchymal development.…”