Synthesis and Biological Activities of Some Novel Triazolothiadiazines and Schiff Bases Derived from 1,2,4-Triazole

Zhou, San-Nu; Zhang, Lixue; Jin, Jiaxu; Zhang, Anjiang; Lei, Xinxiang; Lin, Jianshuang; He, Jiangwei; Zhang, Haile

doi:10.1080/10426500600976884

Cited by 13 publications

(10 citation statements)

References 5 publications

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“…Derivatives of 1,2,4-triazole possess a wide spectrum of biological activity, such as anticancer, anticonvulsant, analgesic, antibacterial, anthelmintic, antitubercular and anti-inflammatory activities (Holla et al, 2003;Bekircan & Bektas, 2006;Zhou et al, 2007). Similarly 1,3,4-thiadiazoles were also found to possess antitumor, anti-inflammatory, antibacterial, antifungal, anticonvulsant and antitubercular properties (Bhat et al, 2004;Mathew et al, 2007).…”

Section: Related Literaturementioning

confidence: 99%

4-Bromobenzoic acid–6-(4-bromophenyl)-3-methyl-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole (1/1)

et al. 2012

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Key indicators: single-crystal X-ray study; T = 293 K; mean (C-C) = 0.007 Å; R factor = 0.048; wR factor = 0.116; data-to-parameter ratio = 15.2.In the title 1:1 co-crystal, C 10 H 7 BrN 4 SÁC 7 H 5 BrO 2 , the triazolothiadiazole system is approximately planar [with a maximum deviation of 0.030 (4) Å ] and forms a dihedral angle of 8.6 (1) with the bromophenyl ring. In the carboxylic acid molecule, the carboxyl group is rotated by 6.4 (3) out of

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Section: Related Literaturementioning

confidence: 99%

4-Bromobenzoic acid–6-(4-bromophenyl)-3-methyl-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole (1/1)

et al. 2012

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“…The hybrid molecules composed of the combination of a heterocyclic ring and a Schiff base may exert potentially biological activities. Some Schiff bases bearing triazoles have been reported to be used as drugs with considerable biological activities [10][11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of some novel Schiff bases containing 1,2,4-triazole ring

et al. 2010

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KEYWORDS4-Allyl-5-piridine-4-yl-4H-1,2,4-triazole-3-thiol was prepared under facile condition via the formation of 2-isonicotinoyl-N-allylhydrazinecarbothioamide. In addition, ethyl[(4-allyl-5-pyridine-4-yl-4H-1¸2¸4-triazole-3-yl)thio]acetate was synthesized via the reaction of 4-allyl-5-piridine-4-yl-4H-1,2,4-triazole-3-thiol with ethyl chloroacetate. 2-[(4-Allyl-5-pyridine-4-yl-4H-1,2,4-triazole-3-yl)thio]acetohydrazide obtained by using ethyl[(4-allyl-5-pyridine-4-yl-4H-1¸2¸4-triazole-3-yl)thio]acetate as a precursor by two steps, was converted to Schiff base derivatives, 6a-j. All synthesized compounds were characterized by elemental analyses, IR spectroscopy, 1 H NMR and 13 C NMR spectroscopy. The cis/trans conformers of E isomer were present in DMSO solution of compounds 6a-j.

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“…In particular, triazoles and their heterocyclic derivatives have been reported to be used as drugs and to have considerable biological activities (analgesic, anthelmintic, antitubercular, plant growth regulating, antiviral, antifungal and anticancer properties) [4][5][6][7][8][9]. 3-Substituted-4-amino-1,2,4-triazole-5-thione is a key synthon in the formation of heterocyclic compounds.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Biological Evaluation of Some Novel Schiff’s Bases from 1,2,4-Triazole

Chen

Zhang

et al. 2007

Molecules

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Abstract:We have synthesized a number of novel Schiff's bases from 4-amino-3-(Dglucoheptonic-hexitol-1-yl)-1H-1,2,4-triazole-5-thione. By attaching D-glucoheptonichexitol-1-yl residues to 1,2,4-triazole at the 3-position, the solubility of the title compounds has been improved greatly. All the products have been characterized by elemental analysis, IR, 1 H-NMR, 13 C-NMR and MS. The plant-growth regulating effects of the title compounds were examined. From the biological activity results, we found that most compounds showed weak to moderate activities.

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Synthesis and Biological Activities of Some Novel Triazolothiadiazines and Schiff Bases Derived from 1,2,4-Triazole

Cited by 13 publications

References 5 publications

4-Bromobenzoic acid–6-(4-bromophenyl)-3-methyl-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole (1/1)

4-Bromobenzoic acid–6-(4-bromophenyl)-3-methyl-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole (1/1)

Synthesis of some novel Schiff bases containing 1,2,4-triazole ring

Synthesis and Biological Evaluation of Some Novel Schiff’s Bases from 1,2,4-Triazole

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