Synthesis and Biological Activities of Some 1,3-Benzoxazol-2(3H)-One Derivatives as Anti-Quorum Sensing Agents

Abstract

Turkey, and they were within the range of ± 0.4 % of the theoretical value. General procedure for the synthesis of 6/5-methyl-1,3-benzoxazol-2(3H)-one derivatives (11 and 16): The mixture of 5-methyl-2-aminophenol or 4-methyl-2-aminophenol (0.1 mol) and urea (0.3 mol) was heated to 140 °C and stirred for 10 min under microwave irradiation (MWI). Reaction mixture was poured onto crushed ice. The precipitated solid product was collected by suction fi ltration, washed with water and dried (compound 11: yield 75 %, compound 16: yield 77 %). General procedure for the synthesis of 3-acyl-1,3-benzoxazol-2(3H)-one derivatives: The acyl chloride (11 mmol) was added dropwise over 15 min to a solution of 1,3-benzoxazol-2(3H)-one derivatives (10 mmol) and dry TEA (11 mmol) in 10 mL of dry THF cooled at − 4 °C. The reaction mixture was