Synthesis and Biological Activities of Griseofulvin Analogs

The Chemistry of Griseofulvin

“…Consequently, several A ring analogs and all B ring and position 6′ analogs have been prepared by strategies developed for the total synthesis of 1 . The strategies used were oxidative cyclization, Diels–Alder, double Michael addition, Dieckmann cyclization, and the improved Michael strategy. ,− …”

“…Structures of miscellaneous analogs prepared by de novo synthesis: 71 (ref , note: inconsistent data regarding stereochemistry), 72 (ref ), 73 (ref ), 74 (ref ), 75 (ref ), 76 (ref ), and 77 (ref ).…”