Synthesis and biological activities of substituted 2- and 3-chloropropylthiophenes

Surikova, T. P.; Zakharova, V. D.; Mochalov, S. S.; Shabarov, Yu. S.

doi:10.1007/bf00764665

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2023

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“…For example, thermal degradation of various arylpyrazolines yields 70-90% of the desired product [8]. In the case of 5-(thiophen-2-yl)-pyrazoline, the yield of 2-cyclopropylthiophene is a modest 26%, at best [16].…”

Section: Introductionmentioning

confidence: 99%

Palladium-Catalyzed Synthesis of Cyclopropylthiophenes and Their Derivatization

et al. 2023

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The cyclopropylthiophene moiety has attracted the attention of the scientific community for its potential pharmaceutical applications. However, synthesis of the compounds containing this framework remains challenging, has rarely been reported and remains unresolved. Here we provide optimized syntheses for cyclopropylthiophenes and their derivatives, containing carbonyl, acetyl, carboxylic acid, methyl carboxylate, nitrile, bromide and sulfonyl chloride moieties.

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Section: Introductionmentioning

confidence: 99%