Synthesis and Biological Activities of Coenzyme Q Derivatives Containing (4-Aryloxylaryl)amino Moiety

Switchable and Scalable Heteroarylation of Primary Amines with 2-Chlorobenzothiazoles under Transition-Metal-Free and Solvent-Free Conditions

“…The only exception was the reaction of 1a with 4-nitroaniline ( 2n ), which only afforded mono-heteroarylation product 3n in 75% yield. In the case of potentially bioactive substructures such as Ph, OPh, − or NHPh as a para substituent, 3o – q (or 4o – q ) were isolated in moderate to high yield under the base-free (or NaH-promoted) condition. Afterward, the influence of the substituent positions on the C–N coupling reactions was evaluated.…”

3,5-Diaryl substituted sclerotiorin: a novel scaffold of succinate-ubiquinone oxidoreductase inhibitors

“…21–23 Accordingly, it is of great significance to synthesize and utilize their analogs as ideal candidates for the development of medicines and pesticides. 24–26 Through structural modifications, these analogs could give rise to novel structures with improved biological activities, new modes of action, and increased safety towards living beings. Consequently, natural product-based structural modifications are ideal for identifying new lead molecules with useful functionalities.…”

Metal-Free Synthesis of Heteroaryl Amines or Their Hydrochlorides via an External-Base-Free and Solvent-Free C–N Coupling Protocol

“…In general, the transition-metal-catalyzed C–N cross-coupling of aryl halides and amines has been regarded as a powerful tool to access these compounds . Although many other metals are employed, Pd has become the metal of choice in most cases due to its efficiency, scope, and applicability . Meanwhile, many research groups have focused on developing versatile ligands to constantly improve this method since these ligands play a pivotal role in the regulation of reaction efficiency .…”