Synthesis and Biological Activities of 2,6-Diaryl-3methyl-4-piperidone Derivatives.

Rameshkumar, Natesh; Veena, Anantharaman; Ilavarasan, R.; Adiraj, Mandaleeswaran; Shanmugapandiyan, P.; Sridhar, S.

doi:10.1248/bpb.26.188

Cited by 72 publications

(34 citation statements)

References 8 publications

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“…They are also used as corrosion inhibitors. The reports 7 indicated that the biological activities of piperidin-4-ones were associated with the substituents at 2,3 and 6 positions. The biological activity was found to be significant in compounds possessing aromatic substituents in 2 and 6 positions.…”

Section: Oriental Journal Of Chemistrymentioning

confidence: 99%

Synthesis, Characterization and Antibacterial Studies on Copper(II) Binuclear Complexes with Substituted Piperidin-4-ones

Theivarasu¹,

Sivaprakash²

2012

Orientjchem.

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Copper(II) Chloride binuclear complexes with variously substituted 2,6-diphenly piperidin-4-ones [Cu 2 LCl 4 (H 2 O) 3 ] have been synthesized and characterized by elemental analysis, molar conductance, magnetic susceptibility measurements, thermal and spectral studies. Molar conductance data show that these complexes are non-electrolytes. The presence of three coordinated water molecules is confirmed by thermal and infrared spectral studies. IR spectral data indicate that the piperidin-4-ones are monodentate and coordinate only through ring nitrogen. The electronic spectral and magnetic studies suggest distorted square-pyramidal environment for Cu(II) complexes. Antibacterial activities of the ligands and their complexes have been tested against bacterial culture by disc diffusion method. It has been found that all the complexes have higher activity than the free ligands.

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Section: Oriental Journal Of Chemistrymentioning

confidence: 99%

Synthesis, Characterization and Antibacterial Studies on Copper(II) Binuclear Complexes with Substituted Piperidin-4-ones

Theivarasu¹,

Sivaprakash²

2012

Orientjchem.

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“…A number of hydrazones derivatives of aldehydes and ketones have been synthesizedand their biological activities like antimicrobial, antibiofilm,antitubercular,antitumoral, antimalarial activities are well reported in literature (2)(3)(4)(5)(6)(7)(8)(9) . Heterocyclic compounds containingpiperidine skeleton are wellestablished group of compounds possessing interestingpharmacological activities and their wide occurrence in nature.Piperidines with aryl substituent at carbons 2 and 6 of piperidine ring have been reported as potent antimicrobial agent (10)(11)(12) . …”

Section: Introductionmentioning

confidence: 99%

Antibiofilm Activities of some Synthesized Hydrazones on Solid Surfaces

Vijayakumar¹,

Brainard²

2018

IJERT

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Abstract-Hydrazones are interesting group of compounds possessing diverse biological and pharmaceutical properties such as antimicrobial, anti-inflammatory, antimalarial, antimycobacterial, antiviral, anticancer, antibiofilm activities, etc. The present study highlights the synthetic aspects of4-aminobenzoylhydrazones of3,5-dimethyl-2,6-diphenyl piperidin-4-one and 3-ethyl 2,6-diphenyl piperidin-4-one.The synthesized compounds are characterized by IR, NMR and Mass spectral studies. Formation of hydrazonecompounds were ascertained by IR,1HNMR and13C NMR spectralstudies and also molecular ion peak in mass spectra confirm the formation of hydrazones. Antibacterial,antifungal and antibiofilmpotential of the synthesized hydrazones are explored by agar well diffusion method and the measurement of zone of inhibition shows that they exhibit significant activity against tested bacteria and fungus.

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“…Piperidin-4-one molecules are well known for their therapeutic applications and therefore great effort is directed toward the synthesis and characterisation of new derivatives. Specifically, piperidine derivatives are reported to exhibit anti-bacterial [12,13] anti-fungal, central nervous system (CNS) stimulating, depressant and analgesic [14,15], antitubercular [16], anti-cancer [17,18] anti-oxidant and anticonvulsant [19] activities. The significant biological activities of piperidin-4-one derivatives are often associated with the aryl substituents at the positions on either side of the amine group [18,20].…”

Section: Introductionmentioning

confidence: 99%

Hydrogen bonding in 2,6-bis(4-fluorophenyl)-3,5-dimethylpiperidin-4-one methanol solvate

Suresh¹,

Vijayakumar

Kumar

et al. 2016

Zeitschrift Für Kristallographie - Crystalline Materials

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Hydrogen bonding in 2,6-bis(4-fluorophenyl)-3,5-dimethylpiperidin-4-one methanol solvate 72S.docx 30.10.2017 1 (21) Hydrogen bonding in a piperidin-4-one Keywords: Piperidin-4-one / conformation / DFT / crystal structure analysis / X-ray diffraction Abstract. The crystal structure analysis of a 2,6-diaryl 4-piperidone derivative, isolated as a mono-methanol solvate, reveals that both the piperidone and the methanol molecule lie on a crystallographic mirror plane. A chair conformation is found for the piperidone ring with the aryl and methyl groups in equatorial positions. The most prominent feature of the molecular packing is the formation of supramolecular zigzag chains mediated by amine-N-H…O(methanol) and hydroxyl-O-H…N(amine) hydrogen bonds, i.e. the methanol molecule serves as a bridge between piperidone molecules. The molecular structure is compared with that determined in an unsolvated form and the gas-phase equilibrium structure, obtained using density-functional theory (DFT); differences relate, in the main, to the relative dispositions of the aryl rings. An analysis of the Hirshfeld surfaces of the experimental structures indicates very similar relative contributions with the notable exception being the contribution by O…H/H…O which at 13.7% in the methanol solvate is greater than 8.5% in the unsolvated form.

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Synthesis and Biological Activities of 2,6-Diaryl-3methyl-4-piperidone Derivatives.

Cited by 72 publications

References 8 publications

Synthesis, Characterization and Antibacterial Studies on Copper(II) Binuclear Complexes with Substituted Piperidin-4-ones

Synthesis, Characterization and Antibacterial Studies on Copper(II) Binuclear Complexes with Substituted Piperidin-4-ones

Antibiofilm Activities of some Synthesized Hydrazones on Solid Surfaces

Hydrogen bonding in 2,6-bis(4-fluorophenyl)-3,5-dimethylpiperidin-4-one methanol solvate

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