Synthesis and Biological Activities of Novel Pyrazole Oxime Derivatives Containing a 2-Chloro-5-thiazolyl Moiety

Abstract

A series of novel pyrazole oxime derivatives containing a 2-chloro-5-thiazolyl moiety were synthesized. Their structures were confirmed by (1)H NMR, (13)C NMR, and elemental analysis. The preliminary bioassays showed that all of the title compounds had low acaricidal activity against Tetranychus cinnabarinus . However, most of them exhibited excellent insecticidal activity against Aphis medicagini at the dosage of 0.5 mg/mL, and some compounds still showed good insecticidal activity against A. medicagini even at the dosage of 0.2 mg/mL. Meanwhile, some title compounds displayed fungicidal and plant growth regulatory activities.

Synthesis and anti-bacterial activity of novel 1,3-pheylene-bis-N-acetyl- and N-phenylpyrazole derivatives

“…[9][10][11] For thus, pyrazole derivatives have attracted considerable attention in the recent years for their diverse biological activities. [12][13][14][15][16][17] In this paper, the novel 1,1'-(5,5'-(1,3-phenylene)bis(3-aryl-4,5-dihydro-1H-pyrazole-5,1-diyl))diethanone (5a-e) and 1,3-bis(1-phenyl-3-(aryl)-4,5-dihydro-1H-pyrazol-5-yl)benzene (6a-e) were synthesized in good yields and evaluated the antibacterial activities of compounds (5a-e) against some human pathogenic bacteria.…”

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“…To innovations in biotechnology for sustainable development of agriculture belongs the elaboration of new PGRs on the basis of low molecular weight synthetic heterocyclic compounds (LMWHC), derivatives of pyridine, pyrimidine, pyrazole, triazine, and oxazole to intensify plant growth and development, and increase crop productivity. As is known LMWHC are widely used in the medicine as drugs for the treatment of bacterial, infectious, viral, fungal, inflammatory, neural, allergic, cancer, and autoimmune diseases [42][43][44][45][46][47][48][49][50][51][52][53][54][55], and in the agriculture as PGRs, herbicides, fungicides, insecticides, acaricides, and antibacterial agents [56][57][58][59][60][61][62][63][64][65][66][67][68][69][70][71]. Our numerous works devoted to study of plant growth regulatory activity of LMWHC, synthesized in the Institute of Bioorganic Chemistry and Petrochemistry of NAS of Ukraine, showed that different classes of LMWHC used at very low non-toxic for human health and environment concentrations 10 -8 M -10 -9 M revealed the broad spectrum of biological action on various crops [72][73][74][75] …”

Design, Synthesis and Bioactivities of Novel Dichloro-Allyloxy-Phenol-Containing Pyrazole Oxime Derivatives

“…Pyrazole oximes are an important class of heterocyclic compounds which have drawn intense attention because of their good fungicidal [1,2], insecticidal [3][4][5], acaricidal [6], and anti-tobacco mosaic virus (TMV) activity [7]. For instance, Fenpyroximate (Figure 1), a potent agricultural acaricide with a vital pyrazole oxime backbone in the structure, possesses wonderful acaricidal property against some phytophagous mites such as Polyphagotarsonemus latus Banks and Tetranychus urticae Koch on different crops [8].…”