Synthesis and biological activities of a nitro-shiff base compound as a potential anti-inflammatory agent

Roriz, Beatriz Cardoso; Buccini, Danieli Fernanda; Santos, Beatriz F. dos; Silva, Suellen Rolon de Sousa; Domingues, Nelson Luís de Campos; Moreno, Susana Elisa

doi:10.1016/j.ejps.2020.105300

Cited by 10 publications

(8 citation statements)

References 57 publications

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“…The production of NO was also estimated in vivo and in vitro . Results showed that the compound 97 ( Figure 19 ) efficiently inhibited inflammation and might be a good candidate for the treatment of inflammatory-associated conditions 112 .…”

Section: Recent Development In Anti-inflammatory Agentsmentioning

confidence: 99%

Small molecule compounds with good anti-inflammatory activity reported in the literature from 01/2009 to 05/2021: a review

Bian

Wu³

et al. 2021

Journal of Enzyme Inhibition and Medicinal Chemistry

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Inflammation and disease are closely related. Inflammation can induce various diseases, and diseases can promote inflammatory response, and two possibly induces each other in a bidirectional loop. Inflammation is usually treated using synthetic anti-inflammatory drugs which are associated with several adverse effects hence are not safe for long-term use. Therefore, there is need for anti-inflammatory drugs which are not only effective but also safe. Several researchers have devoted to the research and development of effective anti-inflammatory drugs with little or no side effects. In this review, we studied some small molecules with reported anti-inflammatory activities and hence potential sources of anti-inflammatory agents. The information was retrieved from relevant studies published between January 2019 and May, 2021 for review. This review study was aimed to provide relevant information towards the design and development of effective and safe anti-inflammation agents.

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Section: Recent Development In Anti-inflammatory Agentsmentioning

confidence: 99%

Small molecule compounds with good anti-inflammatory activity reported in the literature from 01/2009 to 05/2021: a review

Bian

Wu³

et al. 2021

Journal of Enzyme Inhibition and Medicinal Chemistry

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“…That is, there is a nitro- Schiff base complex to Fe. Roriz and colleagues ( 55 ) report that nitro-Schiff bases are possible anti-inflammatory agents, reducing the migration of neutrophils recruited to the site. Within this scenario, compound C3 may have acted topically at the site of infection, and it may have contributed to a decrease in the migration of defense cells to the site of infection.…”

Section: Discussionmentioning

confidence: 99%

Schiff bases complexed with iron and their relation with the life cycle and infection by Schistosoma mansoni

et al. 2022

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IntroductionThe trematode Schistosoma mansoni causes schistosomiasis, and this parasite’s life cycle depends on the mollusk Biomphalaria glabrata. The most effective treatment for infected people is administering a single dose of Praziquantel. However, there are naturally resistant to treatment. This work has developed, considering this parasite’s complex life cycle.MethodsThe synthetics compound were evaluated: i) during the infection of B. glabrata, ii) during the infection of BALB/c mice, and iii) during the treatment of mice infected with S. mansoni.Results and DiscussionFor the first objective, snails infected with miracidia treated with compounds C1 and C3 at concentrations of 25% IC50 and 50% IC50, after 80 days of infection, released fewer cercariae than the infected group without treatment. For the second objective, compounds C1 and C3 did not show significant results in the infected group without treatment. For the third objective, the mice treated with C3 and C1 reduced the global and differential cell count. The results suggest that although the evaluated compounds do not present schistosomicidal properties when placed in cercariae suspension, they can stimulate an immune reaction in snails and decrease mice’s inflammatory response. In general, we can conclude that compound C1 and C3 has an anti-schistosomicidal effect both in the larval phase (miracidia) and in the adult form of the parasite.

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“…The inflammatory process was performed as describe by Roriz and colleagues [55] and induced by application of 500 µL thioglycolate (Merck, Kenilworth, NJ, USA) 4% per animal (n = 5), in the intraperitoneal region. After 6 h of phlogiston stimulation, the animals were euthanized in a CO 2 chamber.…”

Section: Anti-inflammatory Assay: Neutrophil Migrationmentioning

confidence: 99%

Identification of the Active Principle Conferring Anti-Inflammatory and Antinociceptive Properties in Bamboo Plant

et al. 2021

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Early plants began colonizing earth about 450 million years ago. During the process of coevolution, their metabolic cellular pathways produced a myriad of natural chemicals, many of which remain uncharacterized biologically. Popular preparations containing some of these molecules have been used medicinally for thousands of years. In Brazilian folk medicine, plant extracts from the bamboo plant Guadua paniculata Munro have been used for the treatment of infections and pain. However, the chemical basis of these therapeutic effects has not yet been identified. Here, we performed protein biochemistry and downstream pharmacological assays to determine the mechanisms underlying the anti-inflammatory and antinociceptive effects of an aqueous extract of the G. paniculata rhizome, which we termed AqGP. The anti-inflammatory and antinociceptive effects of AqGP were assessed in mice. We identified and purified a protein (AgGP), with an amino acid sequence similar to that of thaumatins (~20 kDa), capable of repressing inflammation through downregulation of neutrophil recruitment and of decreasing hyperalgesia in mice. In conclusion, we have identified the molecule and the molecular mechanism responsible for the anti-inflammatory and antinociceptive properties of a plant commonly used in Brazilian folk medicine.

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Synthesis and biological activities of a nitro-shiff base compound as a potential anti-inflammatory agent

Cited by 10 publications

References 57 publications

Small molecule compounds with good anti-inflammatory activity reported in the literature from 01/2009 to 05/2021: a review

Small molecule compounds with good anti-inflammatory activity reported in the literature from 01/2009 to 05/2021: a review

Schiff bases complexed with iron and their relation with the life cycle and infection by Schistosoma mansoni

Identification of the Active Principle Conferring Anti-Inflammatory and Antinociceptive Properties in Bamboo Plant

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