Synthesis and Biological Activities of Dehydrodiisoeugenol: A Review

Abstract

Dehydrodiisoeugenol (DHIE) is a neolignan found in more than 17 plant species, including herbs, fruit, and root. DHIE was, for the first time, isolated from Myristica fragrans bark in 1973. Since then, many methodologies have been used for the obtention of DHIE, including classical chemistry synthesis using metal catalysts and biocatalytic synthesis; employing horseradish peroxidase; peroxidase from Cocos nucifera; laccase; culture cells of plants; and microorganisms. Increasing evidence has indicated that DHIE has a wide range of biological activities: anti-inflammatory, anti-oxidant, anti-cancerogenic, and anti-microbial properties. However, evidence in vivo and in human beings is still lacking to support the usefulness potential of DHIE as a therapeutic agent. This study’s review was created by searching for relevant DHIE material on websites such as Google Scholar, PubMed, SciFinder, Scholar, Science Direct, and others. This reviews the current state of knowledge regarding the different synthetical routes and biological applications of DHIE.

Anti‐allodynic and anti‐hyperalgesic activity of (±)‐licarin A in neuropathic rats via NO‐cyclic‐GMP‐ATP‐sensitive K+ channel pathway

“…It is obtained from plant families such as Piperaceae , Magnoliaceae , Lauraceae , and Aristolochiaceae . Moreover, (±)‐licarin A has been semi‐synthetically produced from isoeugenol (Godínez‐Chaparro et al, 2022), and several biological activities have been described from it, such as antioxidant (Choong et al, 2005; Fujisawa et al, 2002; Lin et al, 2015), antiparasitic (Abe et al, 2002; Cabral et al, 2010; Meleti et al, 2020; Mengarda et al, 2021; Pereira et al, 2011), antibacterial (Alvarenga et al, 2020; León‐Díaz et al, 2010, 2013), anticancer (Lee et al, 2004; Li et al, 2023; Maheswari et al, 2018; Mbaveng et al, 2021), antidiabetes (Saptarini et al, 2014), antiobesity (Yoon et al, 2018), and antiinflammatory (Fujisawa et al, 2002; Matsui et al, 2015; Murakami et al, 2005) activity.…”