Synthesis and Biodistribution of Cat's Eye-shaped [⁵⁷Co]CoO@SiO₂Nanoshell Aqueous Colloids for Single Photon Emission Computed Tomography (SPECT) Imaging Agent

Abstract

"Cat's eye"-shaped [ 57 Co]CoO@SiO 2 core-shell nanostructure was prepared by the reverse microemulsion method combined with radioisotope technique to investigate a potential imaging agent for a single photon emission computed tomography (SPECT) in nuclear medicine. The core cobalt oxide nanorods were obtained by thermal decomposition of Co-(oleate) 2 precursor from radio isotope Co-57 containing cobalt chloride and sodium oleate. The SiO 2 coating on the surface of the core cobalt oxide nanorods was produced by hydrolysis and a condensation reaction of tetraethylorthosilicate (TEOS) in the water phase of the reverse microemulsion system. In vivo test, micro SPECT image was acquired with nude mice after 30 min of intravenous injection of [ 57 Co]CoO@SiO 2 core-shell nanostructure.

Isotope Tracers To Study the Environmental Fate and Bioaccumulation of Metal-Containing Engineered Nanoparticles: Techniques and Applications

“…Following administration, MENPs can be eliminated through excretion in feces 53,69 and urine, 53,69 both of which are highly dependent on the nature of MENPs. After intravenous injection in mice, more than 80% of the 10 nm 65 ZnO NPs had been excreted by day 28. 71 A similar high excretion in feces (18.1% at 24 h) for 65 ZnO NPs was also observed in mice after tail vein injection.…”

“…After intravenous injection in mice, more than 80% of the 10 nm 65 ZnO NPs had been excreted by day 28. 71 A similar high excretion in feces (18.1% at 24 h) for 65 ZnO NPs was also observed in mice after tail vein injection. 69 However, fecal excretion of 141 Ce from 141 CeO 2 in rats during the first 24 h accounts for only about 0.08%.…”

“…70 After/during the translocation and redistribution of MENPs in the body, their degradation in the body could occur. Following intravenous injection, 65 Zn-labeled CdSe/CdS/ZnS QDs were mainly taken up by the liver and spleen, which was different from that of ionic 65 ZnCl 2 . 67 However, after 4 weeks, the similar distributions of 65 Zn QDs and 65 ZnCl 2 in the organs indicated substantial degradation of the QDs and release of the label into the Zn pool.…”

“…Following intravenous injection, 65 Zn-labeled CdSe/CdS/ZnS QDs were mainly taken up by the liver and spleen, which was different from that of ionic 65 ZnCl 2 . 67 However, after 4 weeks, the similar distributions of 65 Zn QDs and 65 ZnCl 2 in the organs indicated substantial degradation of the QDs and release of the label into the Zn pool. After 12 weeks, no fluorescence from 65 Zn QDs could be detected in the liver cryosections, further confirming the degradation of 65 Zn QDs in the liver.…”

“…67 However, after 4 weeks, the similar distributions of 65 Zn QDs and 65 ZnCl 2 in the organs indicated substantial degradation of the QDs and release of the label into the Zn pool. After 12 weeks, no fluorescence from 65 Zn QDs could be detected in the liver cryosections, further confirming the degradation of 65 Zn QDs in the liver. In the 5 days following intravenous administration of superparamagnetic iron oxide NPs, metabolization of the iron oxide cores occurred, as revealed by modification of their aspect in the lysosomes of Kupffer cells and macrophages of the splenic red pulp.…”