Synthesis and Bioassay of Oxazolyl/Thiazolyl Selenadiazoles, Thiadiazoles and Diazaphospholes

Abstract

A new class of bis heterocycles, oxazolyl/thiazolyl selenadiazoles, thiadiazoles and diazaphospholes were prepared from phenacylsulfonylacetic acid methyl ester and tested for their antimicrobial and antioxidant properties.

Microwave Assisted Synthesis, Antifungal Activity and DFT Theoretical Study of Some Novel 1,2,4-Triazole Derivatives Containing the 1,2,3-Thiadiazole Moiety

“…1,2,3-Thiadiazoles have also been claimed to have beneficial agricultural applications [21,22], because they exhibit wide spectrum biological activities, such as antiviral [23], herbicidal [24,25], antiamoebic [26] and insecticidal [27] activities. For example, after plant inducers such as tiadinil (TDL) and acibenzolar-S-methyl (BTH) (Figure 2) were discovered, 1,2,3-thiadiazole pesticides have become one of the focuses for developing agrochemicals in academia and industry.…”

Antiviral activity of thiadiazoles, oxadiazoles, triazoles and thiazoles

“…Five-membered heterocyclic compounds have shown a wide range of biological activities, 13 namely thiadiazoles, thiazoles, 1,3,4-oxadiazoles, triazoles, [14][15][16][17][18][19][20][21][22][23][24][25][26][27] in addition to the benzimidazole ring. 28 They have been used as scaffolds for the synthesis of a wide range of agents with versatile activities including antibacterial, 29,30 antifungal, 31,32 analgesic, anti-inflammatory, 23 anticancer 33,34 and antihypertensive activity. 35 These five-membered heterocyclic rings have also proved to have very effective antiviral activity against a wide range of viruses, making them of great value in the antiviral research.…”

Synthesis and Antibacterial Activity of Some New Azo Disperse Dyes Containing Selenium and their Application in Polyester Printing

“…Mount epidemiological studies have related the disorder in selenium-body status with the increased risk of many cancers, including breast cancer [5]. Since there is a great similarity of the chemical properties between sulfur and selenium, in comparison selenium heterocyclic compounds have more biological importance [6][7][8][9][10].…”