Synthesis and bioactivity of novel xanthone and thioxanthone l-rhamnopyranosides

Abstract

Xanthone l-rhamnopyranoside derivative 11 was discovered as one of novel topo-I inhibitors.

Beyond the Antagonism: Self-Labeled Xanthone Inhibitors as Modeled “Two-in-One” Drugs in Cancer Therapy

“…Xanthones represent a valuable category of natural products 7 − 12 because of their prominent pharmacological activities. They are known to serve as inhibitors for various targets such as tumors, 13 , 14 bacteria, 15 , 16 viruses, 17 fungi, 18 and others. 19 − 21 Recently, the fluorescence of xanthones has been investigated for selective labeling and recognition of multiscale chemical or biological species.…”

Recent advances in the synthesis of xanthones and azaxanthones

“…9,10 Substitution of phosphorus oxychloride-zinc chloride by phosphorus pentoxide-methanesulfonic acid (Eaton's reagent) as an acylation catalyst generally led to better results. 18,19,23,24,33,35,40,50,54,59,63,70,[106][107][108][109][110][111][112][113][114][115][116][117][118][119][120][121] Since both of these methodologies had previously been extensively reviewed, 9,10 they will not be discussed herein.…”

Xanthones and Cancer: from Natural Sources to Mechanisms of Action

“…From salicylic acid and phenol in phosphorus pentoxide-methanesulfonic acid [144,170] Benzoxanthone FeCl 3 -Catalyzed, three-components, one-pot [171] Caged xanthones Regioselective Claisen/DielsÀ Alder cascade reaction [151,[172][173][174]175] Haloxanthones From 2-bromofluorobenzenes and salicylaldehydes via palladium-catalyzed acylation-SNAr [167,176,177] Hydroxyxanthone Classical one-step synthesis starting from two aryls induced by Mannich reaction and Eaton's reagents. [167,[178][179][180][181][182] Pyranoxanthones From 1,3-dihydroxyxanthone with different reagents [180] Pyridyl xanthones Ag 2 CO 3 mediated oxidative cyclization [183] Sulfonamides xanthones Eaton's reagent and chlorosulfonic acid [184] Thioxanthones Heteropoly acid, catalytic, under microwave [176,185,186] Toxyloxanthones Regioselective aryne addition and Claisen rearrangement [187] Triazole xanthone…”