Synthesis and bioactivities of novel trifluoromethylated pyrazole oxime ether derivatives containing a pyridyl moiety

Abstract

A variety of novel 3-trifluoromethyl substituted pyrazole oxime ether derivatives containing a pyridyl moiety were designed and synthesized in satisfactory yields. Their structures were confirmed by 1 H NMR, 13 C NMR, and elemental analysis. The preliminary bioassays indicated that some of the title compounds showed potential insecticidal activities against Aphis craccivora, and some compounds also displayed plant growth regulatory activities.

l-Proline as a Valuable Scaffold for the Synthesis of Novel Enantiopure Neonicotinoids Analogs

“…All of these compounds are characterized by their high insecticidal activities against insects and relative safety toward mammals and aquatic life. 17 Encouraged by this, we hereby introduce a new structure developing strategy, using dinotefuran as the lead compound, and a series of novel neonicotinoids derivatives were designed by introducing the enantiopure amino acid L-proline. Therefore, in search of improvement, the length of the carbon chain that connected the nitroguanidine and the L-proline was evaluated against the beetle Xyleborus af f inis.…”

A Convergent Approach for the Synthesis of New Pyrazolyl Bipyridinyl Substituted Coumarin Derivatives as Antimicrobials

“…Bipyridine derivatives exhibit wide range of physiological activities such as anticancer [15], cardiotonic [16], DNA binding properties [17] and antibacterial properties [18]. In addition to that, we came across some pyrazolyl substituted pyridines which have been reported to possess insecticidal [19], antiviral [20] and cardiotinic activities [21].…”

Visible light-induced organo-photocatalyzed route to synthesize substituted pyrazoles

“…4 Furthermore, multisubstituted cyanopyrazoles are well-represented in pharmaceuticals, agrochemicals, and related candidates. 5 Fipronil, pyriprole, pyrafluprole, ethiprole (insecticide), zaleplon (sedative-hypnotic), and lorlatinib (ALK/ROS1 inhibitor) are well-known examples (Fig. 1).…”