Synthesis and bioactivities of heterocyclic lipids as PAF antagonists. 1

Chung, SK; Ban, Shurong; Kim, S.H.; Kim, B.E.; Woo, Soon Hyung; Summers, James Bradley; Conway, Richard G.

doi:10.1016/0960-894x(95)00173-q

Cited by 5 publications

(1 citation statement)

References 13 publications

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“…Interestingly, trans-and terminal epoxides gave only the THF product. Additionally, stoichiometric tributyltin methoxide was used by Chung et al 143 in 1996 for ring opening of a terminal epoxide by a hydroxy group to give 4-[(benzyloxy)methyl]oxetan-2-ylmethanol in 32% yield. Subsequently, Carreira and co-workers 69 used this methodology for synthesis of a bridged bicyclic morpholine; it was also used elsewhere.…”

Section: Synthesis Of Oxetane Derivatives By Intramolecular Cyclizationmentioning

confidence: 99%

Oxetanes: Recent Advances in Synthesis, Reactivity, and Medicinal Chemistry

et al. 2016

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The four-membered oxetane ring has been increasingly exploited for its contrasting behaviors: its influence on physicochemical properties as a stable motif in medicinal chemistry and its propensity to undergo ring-opening reactions as a synthetic intermediate. These applications have driven numerous studies into the synthesis of new oxetane derivatives. This review takes an overview of the literature for the synthesis of oxetane derivatives, concentrating on advances in the last five years up to the end of 2015. These methods are clustered by strategies for preparation of the ring and further derivatization of preformed oxetane-containing building blocks. Examples of the use of oxetanes in medicinal chemistry are reported, including a collation of oxetane derivatives appearing in recent patents for medicinal chemistry applications. Finally, examples of oxetane derivatives in ring-opening and ring-expansion reactions are described.

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Section: Synthesis Of Oxetane Derivatives By Intramolecular Cyclizationmentioning

confidence: 99%

Oxetanes: Recent Advances in Synthesis, Reactivity, and Medicinal Chemistry

et al. 2016

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Progress in the Development of Platelet‐Activating Factor Receptor (PAFr) Antagonists and Applications in the Treatment of Inflammatory Diseases

et al. 2018

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Platelet-activating factor (PAF) and its receptor (PAFr) have been implicated in a wide range of diseases and disorders that originate from the activation of inflammatory pathways. Although the exact structure of the binding site on the PAFr remains unknown, the PAFr is a well-established therapeutic target, and an array of structurally diverse PAFr antagonists have been identified. These include compounds that are structurally similar to the natural PAF ligand, synthetic heterocycles, complex polycyclic natural products, and various metal complexes. This review provides an update on more than 20 years of progress in this area. The development and synthesis of new PAFr antagonists, structure-activity relationship studies, the biological activity of these molecules, and their therapeutic potential are discussed.

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Synthesis and Characterisation of 2,2‐Bis(hydroxymethyl)‐1,3‐diselenolato Metal(II) Complexes Bearing Various Phosphanes

et al. 2009

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Keywords: Steric demand / Selenolato ligands / Phosphane ligands / Hydrogen bonds / X-ray diffractionAn improved synthesis of 4,4-bis(hydroxymethyl)-1,2-diselenolane and the complexation properties of the corresponding diselenolato dianion to group-10 metals are reported. We describe an efficient and straightforward procedure that bypasses the isolation of the malodorous and airsensitive diselenol and starts with the diselenide and an appropriate group-10 metal complex bearing phosphane and chlorido ligands. A series of complexes with various monoand bidentate phosphanes is prepared and characterised by multinuclear NMR spectroscopy, mass spectrometry, and elemental analysis. Furthermore, the structure of most complexes is studied by single-crystal X-ray diffraction to establish their supramolecular arrangement in the solid state. Con-

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Synthesis and bioactivities of heterocyclic lipids as PAF antagonists. 1

Cited by 5 publications

References 13 publications

Oxetanes: Recent Advances in Synthesis, Reactivity, and Medicinal Chemistry

Oxetanes: Recent Advances in Synthesis, Reactivity, and Medicinal Chemistry

Progress in the Development of Platelet‐Activating Factor Receptor (PAFr) Antagonists and Applications in the Treatment of Inflammatory Diseases

Synthesis and Characterisation of 2,2‐Bis(hydroxymethyl)‐1,3‐diselenolato Metal(II) Complexes Bearing Various Phosphanes

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