Synthesis and binding properties of 2<i>H</i>‐1‐benzopyran‐2 one fluorophore‐linked calcium channel antagonist nifedipine (1,4‐dihydropyridine) analogs

Padmanabhan, Seetharamaiyer; Peri, Ravikumar; Rutledge, A.; Triggle, David J.

doi:10.1002/jhet.5570340146

Cited by 2 publications

(2 citation statements)

References 11 publications

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“…A large list of coumarins has been synthesised using this method, for instance, coumarin-3-carboxylic acids, amino-and alkylaminocoumarins, 3-acetylcoumarins, 3-benzoylcoumarins crown ethers and new-bridged heterocycles linked to coumarins [93,108,[118][119][120][121][122][123][124][125][126][127][128][129]. The obtention of coumarins by Knoevenagel reaction has also been performed with methylenes activated by heterocycles [130,131].…”

Section: Knoevenagel Reactionmentioning

confidence: 98%

“…Nifedipine analogues with a coumarin fluorophore linked at different positions of the dihydropyridine ring were also synthesised as potential fluorophore-linked calcium channel antagonists [123]. Also, a calcium indicator structurally based on a coumarin structure was synthesised, which may be useful for the measurement of calcium concentrations in the endoplasmic reticulum of living cells [373].…”

Section: Central Nervous System (Cns)mentioning

confidence: 99%

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Simple Coumarins and Analogues in Medicinal Chemistry: Occurrence, Synthesis and Biological Activity

Borges¹,

Roleira²,

Milhazes³

et al. 2005

CMC

883

458

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Coumarins, also known as benzopyrones, are present in remarkable amounts in plants, although their presence has also been detected in microorganisms and animal sources. The structural diversity found in this family of compounds led to the division into different categories, from simple coumarins to many other kinds of policyclic coumarins, such as furocoumarins and pyranocoumarins. Simple coumarins and analogues are a large class of compounds that have attracted their interest for a long time due to their biological activities: they have shown to be useful as antitumoural, anti-HIV agents and as CNS-active compounds. Furthermore, they have been reported to have multiple biological activities (anticoagulant, anti-inflammatory), although all these properties have not been evaluated systematically. In addition, their enzyme inhibition properties, antimicrobial and antioxidant activities are other foremost topics of this field of research. The present work is to survey the information published or abstracted from 1990 till 2003, which is mainly related to the occurrence, synthesis and biological importance of simple coumarins and some analogues, such as biscoumarins and triscoumarins. Data are also highlighted, concerning the development of new synthetic strategies that could help in drug design and in the work on SAR or QSAR.

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Section: Knoevenagel Reactionmentioning

confidence: 98%

Section: Central Nervous System (Cns)mentioning

confidence: 99%

Simple Coumarins and Analogues in Medicinal Chemistry: Occurrence, Synthesis and Biological Activity

Borges¹,

Roleira²,

Milhazes³

et al. 2005

CMC

883

458

View full text Add to dashboard Cite

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ChemInform Abstract: Synthesis and Binding Properties of 2H‐1‐Benzopyran‐2‐one Fluorophore‐ Linked Calcium Channel Antagonist Nifedipine (1,4‐Dihydropyridine) Analogues.

et al. 1997

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Synthesis and Binding Properties of 2H-1-Benzopyran-2-one Fluorophore-Linked Calcium Channel Antagonist Nifedipine (1,4-Dihydropyridine) Analogues. -Nifedipine analogues (VII), (VIII), and (XI) with a coumarin fluorophore linked at the 2-, 2,6-, and 4-position of the dihydropyridine ring, resp., are synthesized by modified Hantzsch condensation procedures and evaluated for their radioligand binding properties. Attempts to synthesize the nifedipine analogue (XII) having the fluorophore at the 3-position fail. -(PADMANABHAN, S.; PERI, R.; RUTLEDGE, A.; TRIGGLE, D. J.;

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Synthesis and binding properties of 2H‐1‐benzopyran‐2 one fluorophore‐linked calcium channel antagonist nifedipine (1,4‐dihydropyridine) analogs

Cited by 2 publications

References 11 publications

Simple Coumarins and Analogues in Medicinal Chemistry: Occurrence, Synthesis and Biological Activity

Simple Coumarins and Analogues in Medicinal Chemistry: Occurrence, Synthesis and Biological Activity

ChemInform Abstract: Synthesis and Binding Properties of 2H‐1‐Benzopyran‐2‐one Fluorophore‐ Linked Calcium Channel Antagonist Nifedipine (1,4‐Dihydropyridine) Analogues.

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