Synthesis and assessment of poly(acrylic acid)/polyvinylpyrrolidone interpenetrating network as a matrix for oral mucosa cells

Oliver-Urrutia, Carolina; Rosales-Ibáñez, Raúl; García, Ma. Victoria Domínguez; Flores-Estrada, Jaime; Flores-Merino, Miriam V.

doi:10.1177/0885328219883482

Cited by 9 publications

(3 citation statements)

References 38 publications

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“…For the spectrum of AANIPU, the band at 1163 cm À1 of the C O group, indicates the photografting of carboxylic groups to form polyacrylic acid. 62 This reaction is confirmed by the displacement of the band at 1696 cm À1 of C O urethane groups of NIPU, to the stretching band at 1703 cm À1 of polyacrylic acid C O. 41…”

Section: Synthesis Of Nipumentioning

confidence: 85%

Synthesis and surface modification of sunflower oil‐based non‐isocyanate polyurethane: Physicochemical and antibacterial properties

del Pilar Maya,

Torres,

Gartner

2024

J of Applied Polymer Sci

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In this work, non‐isocyanate polyurethane (NIPU) films are synthesized from sunflower oil (SFO) with the object of using a renewable resource and establishing a nonpolluting process. SFO also has the advantage of having a higher level of unsaturation than other commercial oils, which provides more reactive sites to be chemically modified. This feature enables a higher degree of conversion to the two monomers, cyclocarbonate, and polyamine‐polyol. NIPU is obtained from their mixture and further crosslinking at 90°C allows the films with suitable mechanical properties to be used in biomedical applications. However, NIPU does not show antibacterial activity, so the surface must be modified. Two methods are used: layer‐by‐layer coating of alginate‐chitosan, and immersion in tea tree oil (TTO), previously activating the surface with acrylic acid (AANIPU). Surface modifications are confirmed by increased hydrophilicity, thermochemical changes, and a drop in mechanical performance. TTO on NIPU films inhibits bacterial growth against S. aureus and E. Coli. NIPU and AANIPU can be accepted as noncytotoxic, while incorporation of the two agents can produce cytotoxicity. No previous reports of such modifications have been found on NIPU films, which appear as promising alternatives for biomedical applications.

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Section: Synthesis Of Nipumentioning

confidence: 85%

Synthesis and surface modification of sunflower oil‐based non‐isocyanate polyurethane: Physicochemical and antibacterial properties

del Pilar Maya,

Torres,

Gartner

2024

J of Applied Polymer Sci

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“…Also, it has an abrasive effect combined with abrasive agents and carboxymethyl cellulose [ 23 ], which is beneficial for eliminating dental plaque and maintaining toothpaste stability. PVP hydrogel and interpenetrating polymer network of poly(acrylic acid)/PVP are applied in culturing human oral mucosa cells [ 24 , 25 ]. In addition, PVP-carrying drugs with low bioavailability, such as enrofloxacin and clotrimazole, can be used for drug release in the oral cavity [ 26 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

Microbiome-friendly PS/PVP electrospun fibrous membrane with antibiofilm properties for dental engineering

Chen,

Guo,

et al. 2024

Regenerative Biomaterials

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Dental caries is one of the most prevalent and biofilm-associated oral diseases in humans. Streptococcus mutans, with a high ability to form biofilms by adhering to hard surfaces, has been established as an important etiological agent for dental caries. Therefore, it is crucial to find a way to prevent the formation of cariogenic biofilm. Here, we report an electrospun fibrous membrane that could inhibit the adhesion and biofilm formation of S. mutans. Also, the PS/PVP electrospun fibrous membrane altered the three-dimensional biofilm architecture and decreased water-insoluble extracellular polysaccharide production. Notably, the anti-adhesion mechanism which laid in Coulomb repulsion between the negatively charged PS/PVP electrospun fibrous membrane and S. mutans was detected by zeta potential. Furthermore, metagenomics sequencing analysis and CCK-8 assay indicated that PS/PVP electrospun fibrous membrane was microbiome-friendly and displayed no influence on the cell viability of HGE and HOK cells. Moreover, an in vitro simulation experiment demonstrated that PS/PVP electrospun fibrous membrane could decrease colony-forming unit (CFU) counts of S. mutans effectively, and PS/PVP electrospun fibrous membrane carrying calcium fluoride displayed better anti-adhesion ability than that of PS/PVP electrospun fibrous membrane alone. Collectively, this research showed that the PS/PVP electrospun fibrous membrane has potential applications in controlling and preventing dental caries.

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“…The combination of polymers results in interpenetrating polymeric networks, which can be designed to have synergistic effects. 18…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of a polymeric network made of polyethylene glycol and chitosan as a treatment with antibacterial properties for skin wounds

et al. 2020

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Polyethylene glycol has been widely investigated for wound healing and dressing applications. Despite its advantages (i.e. great biocompatibility), polyethylene glycol lacks antibacterial activity. For this reason, semi-interpenetrated polymeric networks were prepared by combining a chemically cross-linked polyethylene glycol network with chitosan. The aim of this work was to identify the best amount of chitosan able to improve the antibacterial properties against Staphylococcus aureus. Briefly, the networks were synthesized by a sequential method, adding chitosan in different proportion to the polyethylene glycol. The antibacterial activity was tested following the MGA 0100 of the Pharmacopeia of the United States of Mexico. Fourier-transform infrared with attenuated total reflection spectroscopy, scanning electron microscopy and swelling behavior PBS at 37° C and room temperature were also performed to characterize the polymeric networks. The results showed that PC-2% was able to inhibit the bacterial growth of Staphylococcus aureus even more than Fosfomycin antibiotic. The networks showed cylindrical pores of different sizes (50–100 µm). The maximum swelling of all the networks was achieved in PBS at 37°C (>315%). Free hemoglobin and hemolysis assays were also evaluated to know the compatibility with erythrocytes. Human dermal fibroblasts were used to evaluate direct cytotoxicity. Therefore, the produced gels exerted interesting antibacterial activity and showed good biocompatibility properties.

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Synthesis and assessment of poly(acrylic acid)/polyvinylpyrrolidone interpenetrating network as a matrix for oral mucosa cells

Cited by 9 publications

References 38 publications

Synthesis and surface modification of sunflower oil‐based non‐isocyanate polyurethane: Physicochemical and antibacterial properties

Synthesis and surface modification of sunflower oil‐based non‐isocyanate polyurethane: Physicochemical and antibacterial properties

Microbiome-friendly PS/PVP electrospun fibrous membrane with antibiofilm properties for dental engineering

Synthesis and characterization of a polymeric network made of polyethylene glycol and chitosan as a treatment with antibacterial properties for skin wounds

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