Synthesis and Applications of Imidazoquinolines: A Review

Facile Condensation of 2‐Aminobenzaldehydes into Azolo[4,5‐b]Quinolones

“…Azolo[4,5‐b]pyridines and their derivatives have a long history of application in the medical research [1] . Some of them exhibiting antimicrobial, [2] anticancer, [3] herbicidal, [4] anti‐aggregating, [5] anti‐inflammatory, [6,7] and other valuable biological activities (Scheme 1).…”

TiCl4‐Mediated Dealkylative Cyclization of Arylidene‐azol‐ones

“…Azolo[4,5‐b]pyridine is a privileged chemical scaffold, which is intensively studied due to diverse biological activities, exhibited by its derivatives [1] . These compounds demonstrate antimicrobial, [2] herbicidal, [3] antiaggregant, [4] anti‐inflammatory [5,6] and other [7] properties (Scheme 1).…”

“…During the study of [1,5]-hydride shift reaction of orthoamino-arylidene-azolones, we have discovered that although the desired reaction proceeds easily for imidazol-4-ones, [13][14][15] substrates with the other heterocyclic fragments often transform into other products under the action of Lewis acids.…”

Novel Derivatives of Tetrahydrobenzo (g) Imidazo[α-1,2] Quinoline Induce Apoptosis Via ROS Production in the Glioblastoma Multiforme Cells, U-87MG

“…Accordingly, efforts are underway to develop more efficient therapeutic approaches to improve patient prognosis and reduce disease-related morbidity (Stylli, 2020). Imidazoquinolines are heterocyclic skeletons generated by the fusion between the 5-membered imidazole ring and the benzopyridine ring, quinolone (Bazin et al, 2018). Evidence indicates that imidazoquinolines exhibited antibacterial, antiparasitic, antiallergic, and anxiolytic effects (Smith et al, 2003;Schwartz et al, 2009).…”