Synthesis and applications of heterobifunctional poly(ethylene oxide) oligomers

Thompson, Michael; Vadala, T. P.; Vadala, Michael L.; Lin, Yen-Chih; Riffle, Judy S.

doi:10.1016/j.polymer.2007.10.029

Cited by 144 publications

(124 citation statements)

References 133 publications

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“…There is a variety of synthetic routes to monofunctional PEG derivatives, mainly relying on either a functional initiator or a suitable terminating agent in the anionic polymerization of ethylene oxide (EO). Furthermore, various heterobifunctional PEGs [3] with two different termini have been reported that offer additional possibilities for bioconjugation.…”

Section: Introductionmentioning

confidence: 99%

Hetero‐Multifunctional Poly(ethylene glycol) Copolymers with Multiple Hydroxyl Groups and a Single Terminal Functionality

Mangold¹,

Wurm²,

Obermeier³

et al. 2010

Macromol. Rapid Commun.

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Hetero-multifunctional poly(ethylene glycol-co-glycerol) random copolymers with multiple hydroxyl functionalities and a single terminal functionality have been prepared by copolymerization of ethylene oxide (EO) and ethoxy ethyl glycidyl ether (EEGE) with the use of a suitable initiator, introducing a protected amino group or a double bond, respectively. Acidic deprotection was used for removal of the acetal protecting groups in the chain, and the terminal amino group was regenerated by catalytic hydrogenation. A series of copolymers with narrow polydispersity was obtained, varying comonomer fractions from 3 to 67% and molecular weights in the range of 5 000-32 000 g · mol(-1) (1.05 < $\overline M _{\rm w} /\overline M _{\rm n}$ < 1.25). Molecular and thermal characterization was carried out using (1) H- and (13) C NMR, SEC and differential scanning calorimetry (DSC).

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Section: Introductionmentioning

confidence: 99%

Hetero‐Multifunctional Poly(ethylene glycol) Copolymers with Multiple Hydroxyl Groups and a Single Terminal Functionality

Mangold¹,

Wurm²,

Obermeier³

et al. 2010

Macromol. Rapid Commun.

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“…PEG is synthesised via ring-opening polymerisation (ROP) of ethylene oxide (EO) with a functionalised initiator, either a hydroxide or alkoxide (Gaucher et al 2005;Tessmar et al 2002;Nagasaki et al 1995a, b;Zhang et al 2004;Nakamura et al 1998;Cammas et al 1995;Xiong et al 2012;Thompson et al 2008). Alternatively, it can be prepared by derivatisation of commercially available HO-PEG-OH (or other homobifunctional PEGs) (Xiong et al 2012;Thompson et al 2008).…”

Section: Hydrophilic Blockmentioning

confidence: 99%

“…Alternatively, it can be prepared by derivatisation of commercially available HO-PEG-OH (or other homobifunctional PEGs) (Xiong et al 2012;Thompson et al 2008). The most convenient route is however to use commercially available functionalised PEGs.…”

Section: Hydrophilic Blockmentioning

confidence: 99%

Polymeric Micelles

Gaal

Crommelin

2015

Non-Biological Complex Drugs

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“…Thompson et. al., have reported that by having alternate long and short chain PEGs the non specific binding has been reduced [28]. Polyethylene glycol, in different forms has proven to be a suitable material for construction of protein-resistant surfaces [29][30][31][32].…”

Section: Reduction Of Non-specific Binding By Incorporation Of Short mentioning

confidence: 99%

PECVD coatings for functionalization of point-of-care biosensor surfaces

Gandhiraman

Gubala

O’Mahony

et al. 2012

Vacuum

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In early stage disease diagnosis, an accurate and reliable measurement of low concentrations of specific biomarkers is a key need. The detection technique requires the reaction of an antibody, which is generally covalently bound to the biosensor platform, with its antigen. The application of Zeonor®, a cyclo olefin copolymer (COP) with very low autofluorescence, good optical properties and high precision molding characteristics, as a biosensor platform has been demonstrated recently. Highly reproducible, industrial scale surface chemical modification of the COP plastic for covalent attachment of the biomolecules for specific recognition of the target, together with low non specific binding of other proteins that may be present in the sample is a key challenge. In this work, the applicability of plasma enhanced chemical vapor deposition (PECVD) process has been demonstrated by depositing varying surface functionalities including amines, carboxylic, mercapto, epoxy and polyethylene glycol functionalities.The plasma functionalized coatings thus created possess both reactive and repellent sites on the biosensor chip, allowing the chip to be configured either for fluorescence or light scattering-based detection or for label-free surface plasmon resonance detection techniques. The versatility of the gas phase deposition process for building sequential chemistries on low cost and disposable plastic chips is presented in detail. * Corresponding Author: Vladimir.gubala@dcu.ie , Ph: +35317006337 IntroductionWith parameters. The effect of ion bombardment on the growing film and the plasma electron density are crucial and could lead to dissociation of functional groups in the plasma as well as on the growing film. In this article, synthetic approaches for modification of COP substrates with -NH 2 and -SH functional groups will be discussed. Perhaps more importantly, we will also provide a review on the analytical tools used to assess the quality of the prepared films. For a design of sensitive bioassay device, it is critical to understand interaction forces in real systems, and how these relate on the one hand to the surface composition and chemistry, and on the other hand to the specificity, sensitivity and resistance to non-specific binding. 2.Materials and methods Plasma Enhanced Chemical Vapor DepositionThe vacuum chamber is an aluminum based container. The pressure in the chamber was measured using a Granville-Phillips gauge. An Edwards EH mechanical booster pump backed by an Edwards E1M40 rotary pump was used to pump down the chamber.The rotary pump was connected through a port at the bottom of the chamber.The powered electrode, 24cm x 21cm plate with a 6cm diameter with a hole in the middle, was placed slightly below the top of the chamber and the chamber wall was grounded. The powered electrode is cooled with running water. Also a 24cm X 21cm X 1.2cm electrically isolated, water cooled hollow metallic setup placed 10 cm away from the powered electrode is used as the substrate holder. The powered electrod...

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Synthesis and applications of heterobifunctional poly(ethylene oxide) oligomers

Cited by 144 publications

References 133 publications

Hetero‐Multifunctional Poly(ethylene glycol) Copolymers with Multiple Hydroxyl Groups and a Single Terminal Functionality

Hetero‐Multifunctional Poly(ethylene glycol) Copolymers with Multiple Hydroxyl Groups and a Single Terminal Functionality

Polymeric Micelles

PECVD coatings for functionalization of point-of-care biosensor surfaces

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