Synthesis and antiviral properties of new derivatives of 2-(alkylsulfanyl)-6-[1-(2,6-difluorophenyl)cyclopropyl]-5-methylpyrimidin-4(3H)-one

Новаков, И. А.; Yablokov, A. S.; Orlinson, B. S.; Navrotskii, M. B.; Kirillov, I. A.; Вернигора, А. А.; Babushkin, A. S.; Качала, В. В.; Schols, Dominique

doi:10.1134/s1070428016080169

Cited by 3 publications

(1 citation statement)

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“…Its subsequent reaction with an acyl chloride at 0 °C led to the efficient preparation of α‐substituted‐β‐ketoesters (Scheme 14). Despite the recent use of this methodology for the preparation of pyrimidin‐4‐one derivatives, [74,75] only methyl‐ and phenyl‐substituted SMAHOs remain described so far, although the reaction is compatible with both aromatic and aliphatic acyl chlorides. In the case of MAHOs, an alternative generation of the magnesium chelate was described by Wemple using MgCl 2 and TEA [76] .…”

Section: Claisen Reactionsmentioning

confidence: 99%

Substituted Malonic Acid Half Oxyesters (SMAHOs): Green Nucleophiles for Organic Synthesis

et al. 2022

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Substituted malonic acid half‐oxyesters (SMAHOs) constitute an original family of malonic acid derivatives. They could be mostly used as pro‐nucleophiles through decarboxylative processes, making them enolate equivalents for the elaboration of greener methodologies. In addition to the native ester function, the presence of a substituent on the malonic position affords additional opportunities for structural diversification. These reagents are particularly well‐suited for the development of organocatalyzed processes, which has recently led to olefination and addition reactions as relevant synthetic routes to elaborated structures under mild conditions.

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Section: Claisen Reactionsmentioning

confidence: 99%