Synthesis and antiviral evaluation of some new pyrazole and fused pyrazolopyrimidine derivatives

Rashad, Aymn E.; Hegab, Mohamed I.; Abdel-Megeid, Randa E.; Micky, Jehan A.; Abdel‐Megeid, Farouk M. E.

doi:10.1016/j.bmc.2008.06.054

Cited by 199 publications

(125 citation statements)

References 19 publications

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“…[1～3] 、抗病毒 [4] 、抗菌 [5,6] 和抗炎 [7] 等, 也有不少关于农药活性方面的报道 [8～10] , 故该类化合物已引起药物学家和农药化学家的广泛关注 . 1,3,4-噻二唑类化合物由于具有杀菌 [11,12] 、杀虫 [13] 、除草 [14,15] 和调节植物生长 [16～18] 等广泛的生物活性而倍受青睐, 而且硫醚类化合物也是一类具有抗菌活性的化合物 [11,19] .…”

Section: 吡唑并[34-d]嘧啶类衍生物是一类具有良好生物活性的含氮稠环化合物因吡唑并[34-d]嘧啶的结构与嘌呤环类unclassified

Synthesis and Biological Activity of Pyrazolo[3,4-d]pyrimidine Derivatives Containing 1,3,4-Thiadiazole

Xia¹,

Shao²,

Duan³

et al. 2012

Chin. J. Org. Chem.

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School of Chemical and Environmental Engineering, Hubei University for Nationalities, Enshi 445000)Abstract Twelve novel pyrazolo [3,4-d]pyrimidine derivatives containing a 1,3,4-thiadiazole group were synthesized through cyclization of 5-amino-4-cyano-1-phenylpyrazole with formic acid, followed by chloridization and S N Ar reaction. The structures of all these title compounds were confirmed by IR, 1 H NMR, MS techniques and elemental analysis. The preliminary bioassay showed that most of the title compounds exhibit relatively good fungicidal activities against Rhizoctonia cerealis at the concentration of 50 mg/L, especially the inhibitory rates of compounds 5b, 5d and 5j reach above 90%.

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Section: 吡唑并[34-d]嘧啶类衍生物是一类具有良好生物活性的含氮稠环化合物因吡唑并[34-d]嘧啶的结构与嘌呤环类unclassified

Synthesis and Biological Activity of Pyrazolo[3,4-d]pyrimidine Derivatives Containing 1,3,4-Thiadiazole

Xia¹,

Shao²,

Duan³

et al. 2012

Chin. J. Org. Chem.

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“…Pyrazolo [3,4-d]pyrimidines and their related fused heterocycles are of considerable significance chemical and pharmaceutical utility as purine analogs [3] and many of their derivatives were reported to possess antiviral [1,4] antimicrobial [2,5] anti-inflammatory [6,7] anticancer [8] and xanthine oxidase inhibitor [9] activities.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Isomerization of Some Novel Pyrazolopyrimidine and Pyrazolotriazolopyrimidine Derivatives

et al. 2014

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“…Pyrazolo [3,4-d]pyrimidines were identifi ed as a general class of adenosine receptors (Davies et al, 1983(Davies et al, , 1984. Furthermore, some pyrazolo [3,4-d] pyrimidine derivatives demonstrated signifi cant antiviral activity (Anderson et al, 1990;Rashad et al, 2008). There is not much difference in the basic structures of pyrazolopyrimidines and purines (Holla et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Anti-Hepatitis B Virus Activity of New N⁴-β-D-Glycoside Pyrazolo[3,4-d]pyrimidine Derivatives

El‐Sayed

Ramiz²,

Abdel‐Rahman³

2009

Zeitschrift Für Naturforschung C

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The reaction of 6-hydrazinyl-1,3-dimethylpyrimidine-2,4-(1H,3H)-dione (1) with ethoxymethylenemalononitrile afforded 5-amino-1-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-6-yl)-1H-pyrazole-4-carbonitrile (2). The latter was reacted with formamide and urea affording the corresponding 4-aminopyrazolo[3,4-d]pyrimidines 3 and 4. The reaction of monosaccharide aldoses with 3 and 4 gave stereoselectively the β-N-glycosides 5a -d and 6a -d which were treated with acetic anhydride in pyridine to afford the corresponding acetylated derivatives 7a -d and 8a -d. The prepared compounds were tested for their antiviral activity against hepatitis B virus (HBV) and showed moderate to high activities.

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Synthesis and antiviral evaluation of some new pyrazole and fused pyrazolopyrimidine derivatives

Cited by 199 publications

References 19 publications

Synthesis and Biological Activity of Pyrazolo[3,4-d]pyrimidine Derivatives Containing 1,3,4-Thiadiazole

Synthesis and Biological Activity of Pyrazolo[3,4-d]pyrimidine Derivatives Containing 1,3,4-Thiadiazole

Synthesis and Isomerization of Some Novel Pyrazolopyrimidine and Pyrazolotriazolopyrimidine Derivatives

Anti-Hepatitis B Virus Activity of New N⁴-β-D-Glycoside Pyrazolo[3,4-d]pyrimidine Derivatives

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Synthesis and antiviral evaluation of some new pyrazole and fused pyrazolopyrimidine derivatives

Cited by 199 publications

References 19 publications

Synthesis and Biological Activity of Pyrazolo[3,4-d]pyrimidine Derivatives Containing 1,3,4-Thiadiazole

Synthesis and Biological Activity of Pyrazolo[3,4-d]pyrimidine Derivatives Containing 1,3,4-Thiadiazole

Synthesis and Isomerization of Some Novel Pyrazolopyrimidine and Pyrazolotriazolopyrimidine Derivatives

Anti-Hepatitis B Virus Activity of New N4-β-D-Glycoside Pyrazolo[3,4-d]pyrimidine Derivatives

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Anti-Hepatitis B Virus Activity of New N⁴-β-D-Glycoside Pyrazolo[3,4-d]pyrimidine Derivatives