Synthesis and antiviral activity of 6-nitro-7-oxo-4,7-dihydroazolo-[5,1-c] [1,2,4]-triazines

Microwave Assisted Synthesis of Some New Fused 1,2,4-Triazines Bearing Thiophene Moieties With Expected Pharmacological Activity

“…Fused 1,2,4-triazine systems have also attracted considerable interest in their biological activity. For example 1,2,4-triazolo[5,1-c][1,2,4]triazinones and their sodium salts, along with azoloannelated 1,2,4-triazines, express high activity against different kinds of viruses, including influenza and bird flu (culture H5N1) [ 29 , 30 , 31 ], and several pyrrolotriazine derivatives were identified as potentially active anticancer agents acting on vascular endothelial growth factor receptor (VEGFR) tyrosine kinases [ 32 ].…”

Synthesis of the [2H,15N]-labeled antiviral drug “triazavirine”

“…Experimental 1 H, 13 C, and 15 N NMR spectra of compounds 5В 15 N, 3 15 N, 7 15 N and 8 2 H 3 , 15 N were recorded on a Bruker Avance II 400 spectrometer in DMSO d 6 with SiMe 4 as an internal standard ( 13 C, 1 H) and liquid ammonia as an external standard ( 15 N). The study of compound 1 2 H 3 , 15 N 3 by NMR was per formed on a Bruker Avance 700 spectrometer equipped with a triple resonance probe ( 1 H, 13 C, 15 N).…”

Synthesis and Evaluation of Novel [1,2,4]Triazolo[5,1‐c][1,2,4]‐triazines and Pyrazolo[5,1‐c][1,2,4]triazines as Potential Antidiabetic Agents

“…The most convenient approach to azolo[5,1‐ c ][1,2,4]triazines appears to be annelation of the triazine ring to an azole moiety by means of diazotation of easily accessible aminoazoles, followed by coupling of the obtained diazonium salts with CH‐active compounds and, finally, a heterocyclization into a fused system . In order to estimate effects of an azole ring on biological properties of the fused azolotriazines, aminotriazoles 5a–g and aminopyrazoles 7a–c were used as starting aminoazoles, while diethyl malonate, ethyl nitroacetate, and cyanoacetate were exploited as CH‐active components.…”