Synthesis and Antiviral Activity of Several N-Containing 5α-STEROIDS

Abstract

A study of the antiviral activity of several new hydrazones and amines and amides of 5D-steroids that were synthesized by us earlier found highly and moderately active compounds. The structures of the synthesized compounds were proven using IR, PMR, 13 C NMR, and mass spectral data.Broad spectra of biological activity make steroids and their derivatives promising for discovering new efficacious drugs [1][2][3]. The high antibacterial, antiviral, and antitumor activity of hydrazono-, amino-, and amido-derivatives of the androstane, estrane, and cholestane series [4][5][6][7][8] and the expanded scope of their synthetic analogs helped to find new biological properties of these compounds.In continuation of research on the synthesis of bioactive 5D-steroids from epiandrosterone 1 [9, 10], a transformation product of tigogenin, hydrazones 2-4 were obtained.

Synthesis of Artemisinin–Estrogen Hybrids Highly Active against HCMV, P. falciparum, and Cervical and Breast Cancer

“…Figure 1. Structures of estrone (1), 17β-estradiol (2), fulvestrant (3), 2methoxyestradiol (4), artemisinin (5), dihydroartemisinin(6), and artesunic acid(7).…”

“…Over the last three decades, steroids have become a prime focus of research in the field of medicinal chemistry due to their remarkable and diverse pharmacological properties, such as anticancer, , anti-inflammatory, , antiparasitic, and antiviral activities. , In particular, the two steroid hormones estrone ( 1 ) and 17β-estradiol ( 2 ) (Figure ) attracted a lot of attention, as these two estrogens are known to be involved in the development of various cancer types such as breast, colorectal, prostate, and ovarian cancer . This led to the discovery of many different estradiol derivatives, which revealed to possess promising anticancer activity.…”