Synthesis and antitumor evaluation of 2,3-diarylbenzofuran derivatives on HeLa cells

Benzofuran hydrazones as potential scaffold in the development of multifunctional drugs: Synthesis and evaluation of antioxidant, photoprotective and antiproliferative activity

“…Benzofurans find application in a variety of drugs and in other field of chemistry and agriculture [1]. Therefore, benzofuran derivatives are the important scaffold for drug discovery and possess broad spectrum biological activity like antimicrobial [2][3][4][5][6], anti-viral [7,8] anti-cancer [9][10][11][12][13][14][15][16], anti-Alzheimer [17][18][19][20], anti-hyperlipidemic [21], antinflammatory and anticonvulsivant [22], anti-tubercular [23], anti-pyretic [24] and protein tyrosine phosphatase inhibitors [25]. The benzofuran core is widely distributed in nature, mainly contained in products of secondary plant metabolism.…”

Domino C–C/C–O bond formation: palladium-catalyzed regioselective synthesis of 7-iodobenzo[b]furans using 1,2,3-triiodobenzenes and benzylketones

“…1 ), which is reported to inhibit proliferation of HeLa cells by apoptosis induction. 9 The 7-cyano-2,3-diarylbenzofuran derivative 2 has inhibitory activity towards serine threonine kinase AKT for treating cancer, 10 whereas the 7-methyl-2,3-diarylbenzofuran derivative 3 exhibits binding affinity to α- or β-subtype estrogen receptors. 11 Lastly, the 7-aminoethyl-2,3-diarylbenzofuran derivative 4 is described as a muscle contractant with good urethral action for treatment of urinary incontinence.…”