Synthesis and antitumor activity of 4-hydroxycoumarin derivatives

Recent developments on nano-ZnO catalyzed synthesis of bioactive heterocycles

“…Heterocycles containing this important structural motif exhibit a wide range of pharmaceutical activities that include antibacterial, anti-HIV, antiviral, anticoagulant, antioxidant and anticancer activities [116][117][118][119][120]. Goswami [121] synthesized a wide range of 4-substituted coumarins (60) by the reaction of a wide range of structurally diverse phenols (59) and ethyl acetoacetate (17) or ethyl benzoyl acetate (17c) in the presence of nanocrystalline ZnO as catalyst and pyridine dicarboxylic acid as co-catalyst in acetonitrile under reflux conditions (Table 17).…”

Antioxidant activity of 3-substituted-4-hydoxycoumarin derivatives

“…Otherwise, 4-hydroxycoumarin and its derivatives have drawn much attention due to their wide range of pharmacological effects. Many of them exhibit other important pharmacological properties, including antipyretic and antinociceptive 12 , anti-inflammatory [13][14] , antibacterial 15 , anti-viral 16 , anti-HIV 17 , antioxidant 18 and anti-cancer 19 effects. Thus, the goal of this work was to evaluate the relationship between the structure and the radical scavenging activity of synthetic 3-substituted-4-hydroxycoumarins, namely 3-acetyl-4-hydroxycoumarin, 3-ethoxycarbonyl-4-hydroxycoumarin and 3-acetylphenylhydrazone-4-hydroxycoumarin, in comparison to 4-hydroxycoumarin and BHT used as references (table 1).…”

Highly Efficient and Eco-Friendly One-Pot Synthesis of Penta Substitute Pyrrole Derivatives under Catalyst-Free Conditions

“…Therefore, a simple and efficient method for pyrrole synthesis remains an attractive goal. On the other side, 2-substituted maldrum's acid, derivatives are of much importance because they exist in many natural products and exhibit a wide range of biological activities such as antibacterial, antiviral [8], anticoagulant, anti HIV, anticancer [9] and antioxidant activities [10]. A molecular scaffold which combines both maldrum's acid, and pyrrole moieties might integrate the properties of both, and the hybridization of the both heterocyclic systems in a single nucleus may result in the formation of some valuable molecules from a biological viewpoint.…”