Synthesis and Antitumor Activity of 4‐Hydroxycoumarin Derivatives.

Jung, Jae‐Chul; Lee, Ji-Ho; Oh, Seikwan; Lee, Jae-Gon; Park, Oee‐Sook

doi:10.1002/chin.200514143

Cited by 8 publications

(8 citation statements)

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“…Coumarins received great interest in the literature from synthetic scientists, medicinal chemists and pharmacists because of their exciting, versatile and broad-spectrum biological activities. Coumarin and its derivatives have proven to be significant precursors for synthesizing a wide variety of medicinal agents [7].…”

Section: Introductionmentioning

confidence: 99%

Coumarin sulfonamide derivatives: An emerging class of therapeutic agents

Irfan

Rubab

Rehman

et al. 2020

Heterocyclic Communications

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Coumarin sulfonamide is a heterocyclic pharmacophore and an important structural motif which is a core and integral part of different therapeutic scaffolds and analogues. Coumarin sulfonamides are privileged and pivotal templates which have a broad spectrum of applications in the fields of medicine, pharmacology and pharmaceutics. Coumarin sulfonamide exhibited versatile and myriad biomedical activities such as anti-bacterial, antiviral, antifungal, anti-inflammatory and anti-cancer. This review article focuses on the structural features of coumarin sulfonamide derivatives in the treatment of different lethal diseases on the basis of structure-activity relationships (SAR). The plethora of research cited in this review article summarizes and discusses the various substitutions around the coumarin sulfonamide nucleus which have provided a wide spectrum of biological activities and therapeutic potential that has proved attractive to many researchers looking to exploit the coumarin sulfonamide skeleton for drug discovery and the development of novel therapeutic agents.

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Section: Introductionmentioning

confidence: 99%

Coumarin sulfonamide derivatives: An emerging class of therapeutic agents

Irfan

Rubab

Rehman

et al. 2020

Heterocyclic Communications

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“…Due to the different types of substitution of the parent ring, coumarins are extremely variable in structure resulting in variety of their properties. Both natural and synthetic coumarins are reported to have properties such as antioxidant [7,8], antifungal [9,10], antitumor [11][12][13], anti-HIV [14,15], anticoagulant [16,17], antibacterial [18][19][20], etc. A suggestion has been made that the antibacterial activity depends on the position of substituents and the 3,3'-(4-hydroxybenzylidene)-bis-4-hydroxycoumarin skeleton is essential for the activity [18].…”

Section: Biological Activity Of Coumarin Derivates and Their Lanthanoid Complexesmentioning

confidence: 99%

Assessment of Toxicity Issues of Bis-Coumarine Derivates and their Lanthanoid Complexes by Statistical Data Analysis

Cheng¹,

Yazhen²,

Awan

et al. 2018

BJSTR

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Complexes of some lanthanoids with several biscoumarin compounds such as 3,3'-benzylidenebis(4-hydroxy-2H-chromen-2-one), 3,3'-[(2-methoxyphenyl) methylene)]bis(4-hydroxy-2H-chromen-2-оne), 3'-[(4-methoxyphenyl)methylene)]bis(4-hydroxy-2H-chromen-2-оne) and 3,3'-[(4-chlorophenyl)methylene)]bis(4-hydroxy-2H-chromen-2-оne) were synthesized. The assessment of toxicity both ligands and the complexes formed was made through testing their antibacterial properties and cytotoxicity as two independent activities were studied. Three Grampositive microorganisms were used, B. Mycoides, B. Subtilis and S. Lutea, applying the double layer agar hole diffusion method. The tested compounds were active against Gram-positive bacteria, but no activity was measured against Gram-negative bacteria. Cytotoxicity evaluation was made against cell lines such as K-562, BV-173, and SKW-3. The cluster analysis as a technique of the statistical data analysis was applied to the results obtained.

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“…The derivatives of 4-Hydroxycoumarin ( Figure 1) are of great interest due to their broad spectrum of pharmacological activities including antioxidant (Jung, Park, 2009), anti-allergy (Lee et al, 2004), antiviral (Yu et al, 2003), anti-diabetic (Kontogiorgis, Hadjipavlou-Litina, 2005), anti-HIV (Tosun et al, 2008), anticonvulsant (Sashidhara et al, 2010), anti-tubercular (Jin, Chen, Zhu, 2007), anti-hyperlipidmeic (Hamdi et al, 2011), rodenticidal (Khan et al, 2004) and antifungal (Gao et al, 2010). Some of the 4-Hydroxycoumarin derivatives such as warfarin, coumatetralyl, bromadiolone, flocoumafen and brodifacoum are known due to their anticoagulant (Stanchev et al, 2009;Trivedi et al, 2007), anti-inflammatory (Cardoso et al, 2011), antipyretic, antibacterial (Jung et al, 2004;Manolov, Maichle-Moessmer, Danchev, 2006) antiviral as well as anticancer activities (Inoue et al, 1994;Kostova et al, 2001). The coumarin derivatives are also used in medicines for treatment of renal stones.…”

Section: Introductionmentioning

confidence: 99%

Enzyme inhibition and antibacterial potential of 4-Hydroxycoumarin derivatives

Saleem

Bukhari

Zaidi

et al. 2020

Braz. J. Pharm. Sci.

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The 4-Hydroxycoumarin derivatives are known to show a broad spectrum of pharmacological applications. In this paper we are reporting the synthesis of a new series of 4-Hydroxycoumarin derivatives synthesized through Knovenegal condensation; they were characterized by using UV-Vis, FT-IR, NMR spectroscopies. The synthesized compounds were evaluated for antibacterial activity against Staphylococcus aureus and Salmonella typhimurium strains. The compounds (2), (3) and (8) showed favorable antibacterial activity with zone of inhibitions 26.5± 0.84, 26.0 ± 0.56 and 26.0 ± 0.26 against Staphylococcus aureus (Gram-positive) respectively. However, the compounds (5) and (9) were found more active with 19.5 ± 0.59 and 19.5 ± 0.32 zone of inhibitions against Salmonella typhimurium (Gram-negative). Whereas, in urease inhibition assay, none of the synthesized derivatives showed significant anti-urease activity; although, in carbonic anhydrase-II inhibition assay, the compound (2) and (6) showed enzyme inhibition activity with IC 50 values 263±0.3 and 456±0.1, respectively.

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Synthesis and Antitumor Activity of 4‐Hydroxycoumarin Derivatives.

Cited by 8 publications

References 1 publication

Coumarin sulfonamide derivatives: An emerging class of therapeutic agents

Coumarin sulfonamide derivatives: An emerging class of therapeutic agents

Assessment of Toxicity Issues of Bis-Coumarine Derivates and their Lanthanoid Complexes by Statistical Data Analysis

Enzyme inhibition and antibacterial potential of 4-Hydroxycoumarin derivatives

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