Synthesis and antitumor activity of new silver(I)-N-heterocyclic carbene complexes

Silver(I)‐N‐heterocyclic carbene complexes challenge cancer; evaluation of their anticancer properties and in silico studies

“…The results revealed that substituents around the benzimidazole alter the cytotoxic activity of the complexes. We also found complexes 42 and 43 were more cytotoxic towards MCF‐7 breast cancer cell lines than other cancer cells (Şahin, Şahin‐Bölükbaşı, & Marşan, 2019). In another study of our lab methyl‐substituted complex 44 and isopropyl substituted complex 45 were synthesized and determined that complex 44 was less cytotoxic than complex 45 (Şahin‐Bölükbaşı & Şahin, 2019).…”

“…The most cytotoxic complexes were found to be 40 and 41 that have five and three CH 3 groups in the benzene ring, respectively. These results indicated the additional CH 3 group in the benzene ring can also contribute to the anticancer activity of these complexes (Şahin, Şahin‐Bölükbaşı, & Marşan, 2019). We synthesized complexes 42 and 43, which bear chlorine atom and a methyl group as substituents on the backbone of the benzimidazole ring, respectively.…”

“…Our lab synthesized and characterized a set of Ag(I)‐NHC salts and their Ag(I) complexes ( 31–45 ), (Figure 11) and also investigated their anticancer activity against human breast cancer cells (MCF‐7, MDA‐MB‐231) and human prostate cancer cells (DU‐145) (Çevik‐Yıldız et al, 2020; Şahin, Şahin‐Bölükbaşı, & Marşan, 2019; Şahin, Şahin‐Bölükbaşı, Tahir, et al, 2019; Şahin‐Bölükbaşı et al, 2019; Şahin‐Bölükbaşı & Şahin, 2019). All complexes ( 31–45 ) also applied to L‐929 non‐cancer cells and the selectivity indexes of complexes against cancer cells were determined.…”

“…Structure of Ag(I)–N‐heterocyclic carbene (NHC) complexes ( 31–33 ) (Çevik‐Yıldız et al, 2020), (34–37 ) (Şahin‐Bölükbaşı et al, 2019), (38–41 ) (Şahin, Şahin‐Bölükbaşı, Tahir, et al, 2019), (42–43 ) (Şahin, Şahin‐Bölükbaşı, & Marşan, 2019), (44–45 ) (Şahin‐Bölükbaşı & Şahin, 2019)…”

PC-3 İnsan Prostat Kanser Hücre Hattı Üzerine [1-(2-Metil-2-Propenil)-3-(2-Metilbenzil)Benzimidazolyum Klorür Ligandı ve Bu Ligandın Gümüş(I) Kompleksinin Sitotoksik Aktivitesi

“…Ligand ve kompleks literatüre göre sentezlenmiştir 16 . Bir şilenk içinde hekzan ile yıkanıp kurutulan sodyum hidrür (0.48 g, 20 mmol) üzerine (tetrahidrofuran) THF (30 mL) eklendi ve oda sıcaklığında 1 saat karıştırıldı.…”