Synthesis and antitumor activity of 2,3,10,11-tetramethoxy-5,6,7,8,13,13a-hexahydroprotoberberines and their B-seco analogs

Sladkov, V. I.; Sazonova, N. M.; Grekova, G. S.; Kalistratov, S. G.; Соколова, А. С.; Chernov, V. A.; Суворов, Н. Н.

doi:10.1007/bf00758315

Cited by 3 publications

(2 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[1][2][3][4][5][6][7][8][9][10] The resulting heterocycles have often demonstrated important biological activities, such as cytotoxicity, 11 antitumor, 12,13 cardiotonic, 14 antineoplastic, 15 and many other pharmaceutically useful properties. [16][17][18][19][20] Despite the importance of its synthetic utility, this kind of reaction still has a number of unaccountable features, including the mechanistic details.…”

Section: Introductionmentioning

confidence: 99%

Mechanistic Insights into the Palladium(II)‐catalyzed Intramolecular Cyclization of o‐Alkynylphenylphosphonamide and N‐(o‐Alkynylphenyl)acetamide by Electrospray Ionization Mass Spectrometry

Zhou¹,

Tang²,

Guo³

et al. 2009

Chin. J. Chem.

View full text Add to dashboard Cite

The intramolecular cyclization of o-alkynylphenylphosphonamide and N-(o-alkynylphenyl)acetamide was monitored by electrospray ionization mass spectrometry (ESI-MS) and its tandem version (ESI-MS/MS). The proposed intermediates were successfully intercepted and characterized. In addition, the intermediates composed of the substrate coordinated to the palladium(II) center in the reaction of o-alkynylphenylphosphonamide were unexpected before, and this interesting phenomenon of the substrate coordination seems associated with the unique structure of substrates.

show abstract

Section: Introductionmentioning

confidence: 99%

Mechanistic Insights into the Palladium(II)‐catalyzed Intramolecular Cyclization of o‐Alkynylphenylphosphonamide and N‐(o‐Alkynylphenyl)acetamide by Electrospray Ionization Mass Spectrometry

Zhou¹,

Tang²,

Guo³

et al. 2009

Chin. J. Chem.

View full text Add to dashboard Cite

show abstract

“…Isoquinolin-1-ones have gained considerable synthetic and pharmacological interest for a long time because of their diverse bioactivities, such as antitumor activity, cytotoxicity, cardiovascular activity, antineoplastic property, antimicrobial property, inhibition of human thymidylate synthase, inhibition of PARP activity, and reduction of systolic blood pressure and their potential to serve as novel pharmaceuticals .…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Phosphaisoquinolin-1-ones by Pd(II)-Catalyzed Cyclization of o-(1-Alkynyl)phenylphosphonamide Monoesters

Tang

Ding

2006

J. Org. Chem.

View full text Add to dashboard Cite

A Pd(II)-catalyzed intramolecular cyclization of o-(1-alkynyl)phenylphosphonamide monoethyl esters was examined, and a new class of six-membered phosphorus heterocycles (phosphaisoquinolin-1-ones) were formed with high regioselectivity and good yields. The present reaction is the first example of intramolecular addition of P-NH to substituted alkynes, which provides a valuable way to synthesize novel phosphorus heterocycles with potential bioactivities.

show abstract

Pd(II)-catalyzed coupling–cyclization reaction of o-ethylnylphenylphosphonamides monoesters with allyl halide

Tang

Ding

2008

Tetrahedron

View full text Add to dashboard Cite

Synthesis and antitumor activity of 2,3,10,11-tetramethoxy-5,6,7,8,13,13a-hexahydroprotoberberines and their B-seco analogs

Cited by 3 publications

References 8 publications

Mechanistic Insights into the Palladium(II)‐catalyzed Intramolecular Cyclization of o‐Alkynylphenylphosphonamide and N‐(o‐Alkynylphenyl)acetamide by Electrospray Ionization Mass Spectrometry

Mechanistic Insights into the Palladium(II)‐catalyzed Intramolecular Cyclization of o‐Alkynylphenylphosphonamide and N‐(o‐Alkynylphenyl)acetamide by Electrospray Ionization Mass Spectrometry

Synthesis of Phosphaisoquinolin-1-ones by Pd(II)-Catalyzed Cyclization of o-(1-Alkynyl)phenylphosphonamide Monoesters

Pd(II)-catalyzed coupling–cyclization reaction of o-ethylnylphenylphosphonamides monoesters with allyl halide

Contact Info

Product

Resources

About