Synthesis and antitubercular activity of palladium and platinum complexes with fluoroquinolones

Vieira, Lígia Maria Mendonça; Almeida, Mauro Vieira de; Lourenço, Maria Cristina S.; Bezerra, Flávio A. F. M.; Fontes, Ana Paula Soares

doi:10.1016/j.ejmech.2009.05.001

Cited by 97 publications

(36 citation statements)

References 30 publications

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“…The structure of a metal complex of silver with OFL has not been published yet. By association with patterns obtained so far using OFL, in this study, it is possible to obtain a compound with a stoichiometric metal: ligand of 1:2 or 1:1 while ratio of 1:3 is unlikely [13][14][15][16][17][18][19][20][21]27]. In the mass spectrum (m/z 830.9) is highlighted the molecular ion Ag(OFL) 2 + , corresponding to ratio metal:ligand of 1:2 combination, and m/z 362.1 corresponding to the molecular ion of the free OFL.…”

Section: Ms Spectra Analysismentioning

confidence: 99%

“…Due to the specific complexation ability of fluoroquinolones, in the case of OFL several metalic complexes (Mg 2+ , Ca 2+ , Ba 2+ , Ni 2+ , Zn 2+ , Cu 2+ , Co 2+ , Pd 2+ , Pt 2+ , Bi 3+ ) have been studied before in terms of antimicrobial activity (including Helicobacter pylori and Mycobacterium tuberculosis), binding to DNA and to albumins [13][14][15][16][17][18][19][20][21]. At the moment only a few metal complexes with silver of antibacterial quinolones are known: nalidixic acid, pipemidic acid (first generation), pefloxacin, norfloxacin, ciprofloxacin (second generation), moxifloxacin (fourth generation) [5,6,11,[22][23][24].…”

Section: Introductionmentioning

confidence: 99%

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A New Silver Complex with Ofloxacin – Preliminary Study

Rusu

Popescu

Imre

et al. 2016

Acta Medica Marisiensis

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Objective: Silver complexes of antibacterial quinolones have the potential advantage of combining the antibacterial activity of silver and fluoroquinolones. The objective of our study was the preparation and the preliminary physico-chemical characterization of a silver complex with ofloxacin. Methods: To achieve our goals several spectroscopic methods (ultraviolet spectrophotometry, mass spectrometry, and Fourier transform infrared spectroscopy) and thermal methods (differential scanning calorimetry and thermogravimetric analysis) were used in order to elucidate the chemical structure of the complex. Results: Using mass spectrometry we established the stoichiometric ratio silver:ofloxacin as 1:2. Experimental data suggest a particular coordination for ofloxacin, as a monodentate ligand, in the formation of a complex with silver, through the nitrogen atom from the methyl-piperazine cycle. IntroductionDue to the excellent chelating properties of quinolone antibacterial several metal complexes of these substances were synthesized and studied for their possible antibacterial and antifungal activities. The silver ion is known for its antibacterial and antifungal properties. Fluoroquinolones are synthetic antibacterial agents, with broad spectrum activity, good oral absorption and bioavailability. The 4-oxo and 3-carboxyl groups of fluoroquinolones offer excellent chelating properties for metal ions. Silver complexes of fluoroquinolone antibacterial have the advantage of combining the antibacterial activity of the silver ion with the one of the fluoroquinolone. There are a large number of studies on the complexation of antibacterial fluoroquinolones with metal ions using different metals [1]. Metal complexes have been synthesized with antimicrobial activity equal to or greater with the corresponding quinolone antibacterial. Research on the fluoroquinolone metal complexes has revealed also other biological effects: antifungal, antiparasitic, anticancer, anti-inflammatory, antioxidant and even insulin mimetic [2][3][4]. In the category of metal complexes with promising therapeutic effects are included those containing silver [5][6][7][8][9][10].Complexation of antibacterial quinolones with silver combines the antibacterial activity of Ag (I) with the one of the quinolone. This complexation presents a particular coordination with the quinolone as the monodentate ligand

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Section: Ms Spectra Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A New Silver Complex with Ofloxacin – Preliminary Study

Rusu

Popescu

Imre

et al. 2016

Acta Medica Marisiensis

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show abstract

“…Garoufis et al (2009) reviewed numerous scientific papers on anti-viral, antibacterial and antifungal activity of palladium(II) complexes with different types of ligands (sulfur and nitrogen donor ligands, Schiff base ligands and drugs as ligands). There are other papers in the literature showing different intensity of palladium(II) and platina(IV) complexes activity on various species of bacteria and fungi (Kovala-Demertzi et al, 2001;Brudzinska et al, 2004;Coombs et al, 2005;Guerra et al, 2005;Ali et al, 2006;Manav et al, 2006;Aghatabay et al, 2007;Kizilcikli et al, 2007;Mishra et al, 2007b;Biyala et al, 2008;Al-Hazmi et al, 2008;Vieira et al, 2009). …”

Section: Introductionmentioning

confidence: 99%

From Synthesis to Antibacterial Activity of Some New Palladium(II) and Platinum(IV) Complexes

Radojević¹,

Glođović²,

Vujić³

et al. 2012

Antimicrobial Agents

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“…Quinoline derivatives have demonstrated anti-leishmanial activity, antibacterial, antifungal, anti HIV and antitumor activity [16][17][18][19]. Recently, 4-amino-7-chloro-quinoline derivatives have demonstrated mycobacterium tuberculosis activity [20][21][22][23][24][25][26][27][28][29]. Benzo[h] [1,6]naphthyridine derivatives also showed antimalarial activity 5 [30].…”

Section: Introductionmentioning

confidence: 99%