Synthesis and Antiprotozoal Evaluation of Benzothiazolopyrroloquinoxalinones (V) and (VI), Analogues of Kuanoniamine A.

Abstract

Pyrazine derivatives Pyrazine derivatives R 0550 Synthesis and Antiprotozoal Evaluation of Benzothiazolopyrroloquinoxalinones (V) and (VI), Analogues of KuanoniamineA. -(TAPIA*, R. A.; PRIETO, Y.; PAUTET, F.; WALCHSHOFER, N.; FILLION, H.; FENET, B.; SARCIRON, M.-E.;

Bioactive Marine Alkaloids

“…New pyridoacridine structures provide fertile area for the design and execution of biologically active heterocyclic molecules. 109 Newer synthetic strategies are emerging for efficient assembly of tetracyclic and pentacyclic ring system.…”

Pyrazole‐1‐carbothioamide as a Potent Precursor for Synthesis of Some New N‐heterocycles of Potential Biological Activity

“…As second moiety in this introduction, thiazole has a great component impact of the pharmacophores of a wide number of medicinal significance molecules such as antibacterial , antiprotozoal , and antifungal activities . Moreover, synthetic thiazoles were widely studied and documented as antiproliferative agents , and apoptosis‐inducing and cell division‐inhibiting abilities were reported as anticancer activity mechanism .…”

4‐Chlorothiazole‐5‐carbaldehydes as Potent Precursors for Synthesis of Some New Pendant N‐heterocyces Endowed with Anti‐Tumor Activity

“…Finally, as third motif in this preface, thiazole has an essential component effect of the pharmacophores of a huge number of medicinal significance molecules and the screening of their biological activity, such as antibacterial , antiprotozoal , antitubercular , antifungal , and anthelmintic . Moreover, in vitro anticancer screening researches on diverse 2‐aminothiazole derivatives showed their potent and selective nanomolar inhibitory activity toward a vast range of human tumor cell lines such as breast, lung, leukemia, colon, ovarian, central nervous system, melanoma, prostate, and renal cell lines .…”