Synthesis and antiproliferative activity of 1H-1,2,3-triazole-4H-chromene-d-glucose hybrid compounds with dual inhibitory activity against EGFR/VEGFR-2 and molecular docking studies

Abstract

A series of 1H-1,2,3-triazole−4H-chromene−D-glucose hybrid compound 7a-o were synthesized by using click chemistry of 2-amino-7-propargyloxy-4H-chromene-3-carbonitriles 5a-o and peracetylated D-glucopyaranosyl azide. CuNPs@Montmorillonite K10 was used as catalyst in the presence of...

Triphenylene Discotic Pd(II) Metallomesogens Based on Triazole Ligands Derived from the Click Reaction

“…Up to now, the CuAAC reaction has been extensively applied in various scientific fields, including materials, − medicine, − biology, , and catalysis . One prominent application is utilizing 1,2,3-triazole as a linker group to connect two functional segments.…”

Design, Synthesis and Cytotoxicity of New Coumarin‐1,2,3‐triazole Derivatives: Evaluation of Anticancer Activity and Molecular Docking Studies

“…[9,10] The coumarin molecules are familiar and notorious moities with several applications, and vital action is occurring in arrears to concession of shape and physicochemical properties of the 2-benzopyrone entity. [11][12][13][14] However, coumarin and its derivatives were found to have a wide range of biological and pharmaceutical activities and have been used as good activity agents over decades for the cure of cancer and HIV, [15] coagulant, [16] oxidant [17] and inflammatory [18] and also used as the fascinating aspects to control or to heal of asthma and arthritis. [19] The synthesized derivatives of coumarin and Dgalactose moieties reports of Toan and coauthors showed worthy of action against EGFRÀ L858R and EGFRÀ T790 M tyrosine kinase.…”

“…[20] Mostly, the more active epidermal growth factor receptor (EGFR) can play a vital role in the growth and development of certain belligerent types of breast cancer. [12,13] Indeed, coumarin derivatives are found as essential drug agents for treating metabolic diseases. Furthermore, 4-hydroxycoumarin was used to reduce the reverse transcriptase activity of ACH-2-lymphocyte affected by the HIV [21] and the acylation of hydroxy groups at C-7&C-8 positions of 7,8-dihydroxycoumarin and C-7 position of the 7-hydroxycoumarin skeleton were elucidated the changing of G-protein-coupled receptor activators into inhibitors.…”